OBJECTIVE: This study looks at six different modern wound dressings to investigate how likely they are to cause skin stripping and impairment of the skin's barrier function. METHOD:Healthy volunteers had each dressing applied, removed and reapplied to the skin on their back over the study period of 15 days. Skin barrier function was investigated using the amount of transepidermal water loss (TEWL) and then related to the amount of skin stripping, investigated by measuring stained skin removal, the thickness of the stratum corneum after treatment, and the amount of skin attached to the removed dressings. General signs of trauma, such as skin dryness and erythema, were investigated by subjective and objective parameters. RESULTS:TEWL values measured on the untreated test area, as well as after application of Urgotul Trio, remained relatively unchanged and Mepilex Border decreased slightly (?1g/m2/h), while all other dressings displayed an increased in TEWL: Allevyn Adhesive (5g/m2/h), Versiva XC (14g/m2/h), Comfeel Plus (22g/m2/h) and Biatain (28g/m2/h). By the end of the study, only the untreated area (mean 43% dye remaining), Mepilex Border (76%) and Urgotul Trio (34%) areas had visible dye remaining. It is interesting to note that the untreated site had a colour change, suggesting loss of stratum corneum, due to the shedding of skin cells from the surface. The increase in total skin colour for Comfeel Plus and Biatain after day 8 might be assigned to an increased redness due to erythema. All the dressings showed evidence of stratum corneum attached to the adhesive, except Mepilex Border, which appeared to be free of any attached stratum corneum. CONCLUSION: Overall the best performance in terms of skin protection and failure to cause skin trauma was found to be for Mepilex Border. CONFLICT OF INTEREST: This project was funded by a grant from Mölnlycke Healthcare Ltd.
RCT Entities:
OBJECTIVE: This study looks at six different modern wound dressings to investigate how likely they are to cause skin stripping and impairment of the skin's barrier function. METHOD: Healthy volunteers had each dressing applied, removed and reapplied to the skin on their back over the study period of 15 days. Skin barrier function was investigated using the amount of transepidermal water loss (TEWL) and then related to the amount of skin stripping, investigated by measuring stained skin removal, the thickness of the stratum corneum after treatment, and the amount of skin attached to the removed dressings. General signs of trauma, such as skin dryness and erythema, were investigated by subjective and objective parameters. RESULTS: TEWL values measured on the untreated test area, as well as after application of Urgotul Trio, remained relatively unchanged and Mepilex Border decreased slightly (?1g/m2/h), while all other dressings displayed an increased in TEWL: Allevyn Adhesive (5g/m2/h), Versiva XC (14g/m2/h), Comfeel Plus (22g/m2/h) and Biatain (28g/m2/h). By the end of the study, only the untreated area (mean 43% dye remaining), Mepilex Border (76%) and Urgotul Trio (34%) areas had visible dye remaining. It is interesting to note that the untreated site had a colour change, suggesting loss of stratum corneum, due to the shedding of skin cells from the surface. The increase in total skin colour for Comfeel Plus and Biatain after day 8 might be assigned to an increased redness due to erythema. All the dressings showed evidence of stratum corneum attached to the adhesive, except Mepilex Border, which appeared to be free of any attached stratum corneum. CONCLUSION: Overall the best performance in terms of skin protection and failure to cause skin trauma was found to be for Mepilex Border. CONFLICT OF INTEREST: This project was funded by a grant from Mölnlycke Healthcare Ltd.
Authors: Stephen C Davis; Jie Li; Joel Gil; Jose Valdes; Michael Solis; Ryan Treu; Robert S Kirnser Journal: Int Wound J Date: 2013-09-13 Impact factor: 3.315
Authors: Joyce Black; Michael Clark; Carol Dealey; Christopher T Brindle; Paulo Alves; Nick Santamaria; Evan Call Journal: Int Wound J Date: 2014-03-03 Impact factor: 3.315
Authors: John L Daristotle; Shadden T Zaki; Lung W Lau; Omar B Ayyub; Massi Djouini; Priya Srinivasan; Metecan Erdi; Anthony D Sandler; Peter Kofinas Journal: ACS Appl Mater Interfaces Date: 2020-03-25 Impact factor: 9.229