Literature DB >> 22068135

Site-selective modification of proteins for the synthesis of structurally defined multivalent scaffolds.

Lukas M Artner1, Lars Merkel, Nina Bohlke, Figen Beceren-Braun, Christoph Weise, Jens Dernedde, Nediljko Budisa, Christian P R Hackenberger.   

Abstract

A combination of classical site-directed mutagenesis, genetic code engineering and bioorthogonal reactions delivered a chemically modified barstar protein with one or four carbohydrates installed at specific residues. These protein conjugates were employed in multivalent binding studies, which support the use of proteins as structurally defined scaffolds for the presentation of multivalent ligands. This journal is © The Royal Society of Chemistry 2012

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Year:  2011        PMID： 22068135     DOI： 10.1039/c1cc16039g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  12 in total

1.  Designed ankyrin repeat proteins as scaffolds for multivalent recognition.

Authors:  Jessica J Hollenbeck; Derek J Danner; Rachel M Landgren; Thomas K Rainbolt; Danielle S Roberts
Journal:  Biomacromolecules       Date:  2012-06-21       Impact factor: 6.988

2.  Meeting Proceedings ICBS2016-Translating the Power of Chemical Biology to Clinical Advances.

Authors:  Yugo Kuriki; Toru Komatsu; Peter D Ycas; Sara K Coulup; Erick J Carlson; William C K Pomerantz
Journal:  ACS Chem Biol       Date:  2017-03-17       Impact factor: 5.100

3.  Bioconjugation of green fluorescent protein via an unexpectedly stable cyclic sulfonium intermediate.

Authors:  Ramiz Nathani; Paul Moody; Mark E B Smith; Richard J Fitzmaurice; Stephen Caddick
Journal:  Chembiochem       Date:  2012-05-25       Impact factor: 3.164

4.  A protein-based pentavalent inhibitor of the cholera toxin B-subunit.

Authors:  Thomas R Branson; Tom E McAllister; Jaime Garcia-Hartjes; Martin A Fascione; James F Ross; Stuart L Warriner; Tom Wennekes; Han Zuilhof; W Bruce Turnbull
Journal:  Angew Chem Int Ed Engl       Date:  2014-07-02       Impact factor: 15.336

5.  Orthogonal dual-modification of proteins for the engineering of multivalent protein scaffolds.

Authors:  Michaela Mühlberg; Michael G Hoesl; Christian Kuehne; Jens Dernedde; Nediljko Budisa; Christian P R Hackenberger
Journal:  Beilstein J Org Chem       Date:  2015-05-13       Impact factor: 2.883

6.  Inhibition of peptide aggregation by means of enzymatic phosphorylation.

Authors:  Kristin Folmert; Malgorzata Broncel; Hans V Berlepsch; Christopher Hans Ullrich; Mary-Ann Siegert; Beate Koksch
Journal:  Beilstein J Org Chem       Date:  2016-11-18       Impact factor: 2.883

7.  Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2'-Amino-LNA Functionalized with Galactose Units.

Authors:  Rajesh Kumar; Annika Ries; Jesper Wengel
Journal:  Molecules       Date:  2017-05-21       Impact factor: 4.411

8.  A novel approach to the site-selective dual labelling of a protein via chemoselective cysteine modification.

Authors:  Ramiz I Nathani; Paul Moody; Vijay Chudasama; Mark E B Smith; Richard J Fitzmaurice; Stephen Caddick
Journal:  Chem Sci       Date:  2013-06-18       Impact factor: 9.825

9.  Chemoenzymatic Fc glycosylation via engineered aldehyde tags.

Authors:  Elizabeth L Smith; John P Giddens; Anthony T Iavarone; Kamil Godula; Lai-Xi Wang; Carolyn R Bertozzi
Journal:  Bioconjug Chem       Date:  2014-04-07       Impact factor: 4.774

10.  Directed evolution of multivalent glycopeptides tightly recognized by HIV antibody 2G12.

Authors:  Satoru Horiya; Jennifer K Bailey; J Sebastian Temme; Yollete V Guillen Schlippe; Isaac J Krauss
Journal:  J Am Chem Soc       Date:  2014-04-01       Impact factor: 15.419
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