| Literature DB >> 22068047 |
Stefan Aufderklamm1, Tilman Todenhöfer, Georgios Gakis, Stephan Kruck, Joerg Hennenlotter, Arnulf Stenzl, Christian Schwentner.
Abstract
Thymidine kinases (TK) have a key function in the synthesis of DNA. Two isoenzymes have been characterized: TK1 is cell cycle-dependent and present in the cytoplasm whereas TK2--located in mitochondria--is cell cycle-independent. The diagnostic and prognostic role of TK1 has recently been investigated. TK1 might be helpful for screening and monitoring of human malignancies. TK1 may also serve as a prognostic factor for progression. Herein, we summarize the status of TK1 for cancer monitoring and point out its use as a proliferation marker. A comprehensive overview about the association of TK-1 with various entities is given.Entities:
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Year: 2011 PMID： 22068047 DOI： 10.1016/j.canlet.2011.10.025
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679