BACKGROUND: The study was conducted to investigate correlations between combined oral contraceptive (COC), any progestin-only contraceptive, medicated intrauterine device (MID) or systemic progestin-only (Syst-P) use and tumor marker expression in cervical intraepithelial neoplasia compared to nonusers. STUDY DESIGN: One-hundred ninety-five women of fertile age with cervical biopsies ranging histologically from normal epithelium to carcinoma in situ were recruited consecutively. Combined oral contraceptive, Syst-P and MID users were investigated according to the expression of 11 tumor markers. RESULTS: Overexpression of cyclooxygenase-2 (Cox-2) was observed in COC users, while interleukin 10 was underexpressed. When users of progestogen-only contraceptives were analyzed, there was a lower expression of cytokeratin 10 and interleukin 10. When only MID users were analyzed, a high expression of p53 was found. Expression of Cox-2, p53 and retinoblastoma protein differed between COC and MID users. CONCLUSION: The study showed molecular alterations, which, in general, have not been studied previously in COC users and have never been studied in progestogen-only users. These biological events might be involved in epidemiological correlations found between hormonal contraceptive use and cervical neoplasms.
BACKGROUND: The study was conducted to investigate correlations between combined oral contraceptive (COC), any progestin-only contraceptive, medicated intrauterine device (MID) or systemic progestin-only (Syst-P) use and tumor marker expression in cervical intraepithelial neoplasia compared to nonusers. STUDY DESIGN: One-hundred ninety-five women of fertile age with cervical biopsies ranging histologically from normal epithelium to carcinoma in situ were recruited consecutively. Combined oral contraceptive, Syst-P and MID users were investigated according to the expression of 11 tumor markers. RESULTS: Overexpression of cyclooxygenase-2 (Cox-2) was observed in COC users, while interleukin 10 was underexpressed. When users of progestogen-only contraceptives were analyzed, there was a lower expression of cytokeratin 10 and interleukin 10. When only MID users were analyzed, a high expression of p53 was found. Expression of Cox-2, p53 and retinoblastoma protein differed between COC and MID users. CONCLUSION: The study showed molecular alterations, which, in general, have not been studied previously in COC users and have never been studied in progestogen-only users. These biological events might be involved in epidemiological correlations found between hormonal contraceptive use and cervical neoplasms.
Authors: Megan J Huchko; Hannah Leslie; Jennifer Sneden; May Maloba; Naila Abdulrahim; Elizabeth A Bukusi; Craig R Cohen Journal: Int J Cancer Date: 2013-09-13 Impact factor: 7.396
Authors: Daniel Westreich; Naiomi Jamal; Jennifer S Smith; Doreen Schulze; Sophie Williams; Pam Michelow; Simon Levin; Cynthia Firnhaber Journal: Contraception Date: 2014-01-07 Impact factor: 3.375
Authors: Derek C Johnson; Pema Lhaki; Madhav P Bhatta; Mirjam-Colette Kempf; Jennifer S Smith; Pankaj Bhattarai; Shilu Aryal; Eric Chamot; Kiran Regmi; Sten H Vermund; Sadeep Shrestha Journal: Int Health Date: 2016-04-04 Impact factor: 2.473
Authors: Lisa B Haddad; Alison Swaims-Kohlmeier; C Christina Mehta; Richard E Haaland; Nakita L Brown; Anandi N Sheth; Hsin Chien; Kehmia Titanji; Sharon L Achilles; Davis Lupo; Clyde E Hart; Igho Ofotokun Journal: PLoS One Date: 2020-03-26 Impact factor: 3.240