Literature DB >> 22066413

[Network pharmacology and drug discovery].

Juan Wang1, Xue-jun Li.   

Abstract

The pharmaceutical industry has historically relied on particular families of 'druggable' proteins against which to develop compounds with desired actions. But proteins rarely function in isolation in and outside the cell; rather, proteins operate as part of highly interconnected cellular networks. Network pharmacology is an emerging area of pharmacology which utilizes network analysis of drug action. By considering drug actions in the context of the cellular networks, network analysis promises to greatly increase our knowledge of the mechanisms underlying the multiple actions of drugs. Network pharmacology can provide new approaches for drug discovery for complex diseases. This review introduced the recent progress of network pharmacology and its importance to understand the mechanism of drug actions and drug discovery.

Mesh:

Year:  2011        PMID: 22066413

Source DB:  PubMed          Journal:  Sheng Li Ke Xue Jin Zhan        ISSN: 0559-7765


  3 in total

1.  Mechanisms of Compound Kushen Injection for the Treatment of Lung Cancer Based on Network Pharmacology.

Authors:  Ziqi Meng; Xinkui Liu; Jiarui Wu; Wei Zhou; Kaihuan Wang; Zhiwei Jing; Shuyu Liu; Mengwei Ni; Xiaomeng Zhang
Journal:  Evid Based Complement Alternat Med       Date:  2019-05-28       Impact factor: 2.629

2.  Network Pharmacology Analysis on the Mechanism of Huangqi Sijunzi Decoction in Treating Cancer-Related Fatigue.

Authors:  Yixin Cui; Haiming Wang; Decai Wang; Jiwei Mi; Gege Chen; Fagen Li; Yujia Wang; Yin Zhang
Journal:  J Healthc Eng       Date:  2021-11-18       Impact factor: 2.682

3.  Study on the Multitarget Mechanism and Key Active Ingredients of Herba Siegesbeckiae and Volatile Oil against Rheumatoid Arthritis Based on Network Pharmacology.

Authors:  Xin Yang; Yahui Li; Runlin Lv; Haibing Qian; Xiangyun Chen; Chang Fu Yang
Journal:  Evid Based Complement Alternat Med       Date:  2019-11-26       Impact factor: 2.629

  3 in total

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