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Literature DB >> 22065978

A case of follicular B-cell lymphoma treated using clarithromycin.

Abstract

We report a case of follicular B-cell lymphoma (FL) treated successfully using clarithromycin (CAM). A 44-year-old man who presented with lymphadenopathy was diagnosed with FL after a histological examination of his biopsy specimens. He was administered chemotherapy with R-CHOP (rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone) following which stable disease was achieved. However, the subsequent clinical course showed partial remission of FL and stable disease with tumor regrowth, each of which was treated with chemotherapeutic regimens. Since the patient was diagnosed with leukocytopenia, he could not undergo chemotherapy for the third regrowth; hence, he was administered CAM. His lymphadenopathy regressed and the levels of soluble interleukin 2-receptor decreased. This case shows that treatment using CAM may be effective in some cases of FL.

Entities: Chemical Disease Gene Species

Keywords: Apoptosis; B-cell lymphoma; Clarithromycin; Macrolide; bcl-2

Year: 2011 PMID： 22065978 PMCID： PMC3208206 DOI： 10.5045/kjh.2011.46.3.203

Source DB: PubMed Journal: Korean J Hematol ISSN： 1738-7949

12 in total

1. Prognostic significance of bcl-xL gene expression and apoptotic cell counts in follicular lymphoma.

Authors: Wei-Li Zhao; Marjan Ertault Daneshpouy; Nicolas Mounier; Josette Brière; Christophe Leboeuf; Louis-François Plassa; Elisabeth Turpin; Jean-Michel Cayuela; Jean-Claude Ameisen; Christian Gisselbrecht; Anne Janin
Journal: Blood Date: 2003-09-11 Impact factor: 22.113

2. Six-month oral clarithromycin regimen is safe and active in extranodal marginal zone B-cell lymphomas: final results of a single-centre phase II trial.

Authors: Silvia Govi; Giuseppina P Dognini; Giada Licata; Roberto Crocchiolo; Antonio Giordano Resti; Maurilio Ponzoni; Andrés J M Ferreri
Journal: Br J Haematol Date: 2010-04-28 Impact factor: 6.998

3. Partial regression of duodenal lesions of intestinal follicular lymphoma after antibiotic treatment.

Authors: Tomonori Yaguchi; Hiroyuki Imaeda; Masahiro Kizaki; Naoki Hosoe; Hidekazu Suzuki; Haruhiko Ogata; Yasushi Iwao; Kaori Kameyama; Yasuo Ikeda; Toshifumi Hibi
Journal: Dig Endosc Date: 2010-10 Impact factor: 7.559

4. Antibiotics directly induce apoptosis in B cell lymphoma cells derived from BALB/c mice.

Authors: Tadashi Ohara; Tetsuo Morishita; Hidekazu Suzuki; Tatsuhiro Masaoka; Hiromasa Ishii; Toshifumi Hibi
Journal: Anticancer Res Date: 2004 Nov-Dec Impact factor: 2.480

5. BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma.

Authors: Ruben Niesvizky; David S Jayabalan; Paul J Christos; Jessica R Furst; Tara Naib; Scott Ely; Jessica Jalbrzikowski; Roger N Pearse; Faiza Zafar; Karen Pekle; April Larow; Richard Lent; Tomer Mark; Hearn J Cho; Tsiporah Shore; Jeffrey Tepler; John Harpel; Michael W Schuster; Susan Mathew; John P Leonard; Madhu Mazumdar; Selina Chen-Kiang; Morton Coleman
Journal: Blood Date: 2007-11-07 Impact factor: 22.113

6. Clarithromycin and azithromycin induce apoptosis of activated lymphocytes via down-regulation of Bcl-xL.

Authors: Syunji Mizunoe; Jun-Ichi Kadota; Issei Tokimatsu; Kenji Kishi; Hiroyuki Nagai; Masaru Nasu
Journal: Int Immunopharmacol Date: 2004-09 Impact factor: 4.932

7. Regression of lung lesions in Hodgkin's disease by antibiotics: case report and hypothesis on the etiology of Hodgkin's disease.

Authors: Christian Sauter; Stephan Blum
Journal: Am J Clin Oncol Date: 2003-02 Impact factor: 2.339

8. Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells.

Authors: Rami Hayun; Eitan Okun; Alain Berrebi; Lev Shvidel; Lucette Bassous; Benjamin Sredni; Uri Nir
Journal: Leuk Lymphoma Date: 2009-04

9. Follicular lymphoma international prognostic index.

Authors: Philippe Solal-Céligny; Pascal Roy; Philippe Colombat; Josephine White; Jim O Armitage; Reyes Arranz-Saez; Wing Y Au; Monica Bellei; Pauline Brice; Dolores Caballero; Bertrand Coiffier; Eulogio Conde-Garcia; Chantal Doyen; Massimo Federico; Richard I Fisher; Javier F Garcia-Conde; Cesare Guglielmi; Anton Hagenbeek; Corinne Haïoun; Michael LeBlanc; Andrew T Lister; Armando Lopez-Guillermo; Peter McLaughlin; Noël Milpied; Pierre Morel; Nicolas Mounier; Stephen J Proctor; Ama Rohatiner; Paul Smith; Pierre Soubeyran; Hervé Tilly; Umberto Vitolo; Pier-Luigi Zinzani; Emanuele Zucca; Emili Montserrat
Journal: Blood Date: 2004-05-04 Impact factor: 22.113

10. Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually exclusive.

Authors: Anneke G Bosga-Bouwer; Gustaaf W van Imhoff; Ronald Boonstra; Anneke van der Veen; Eugenia Haralambieva; Anke van den Berg; Bauke de Jong; Vanessa Krause; Martin C Palmer; Robert Coupland; Philip M Kluin; Eva van den Berg; Sibrand Poppema
Journal: Blood Date: 2003-02-01 Impact factor: 22.113

5 in total

A case of follicular B-cell lymphoma treated using clarithromycin.

1. Prognostic significance of bcl-xL gene expression and apoptotic cell counts in follicular lymphoma.

2. Six-month oral clarithromycin regimen is safe and active in extranodal marginal zone B-cell lymphomas: final results of a single-centre phase II trial.

3. Partial regression of duodenal lesions of intestinal follicular lymphoma after antibiotic treatment.

4. Antibiotics directly induce apoptosis in B cell lymphoma cells derived from BALB/c mice.

5. BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma.

6. Clarithromycin and azithromycin induce apoptosis of activated lymphocytes via down-regulation of Bcl-xL.

7. Regression of lung lesions in Hodgkin's disease by antibiotics: case report and hypothesis on the etiology of Hodgkin's disease.

8. Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells.

9. Follicular lymphoma international prognostic index.

10. Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually exclusive.

1. Successful treatment of recurrent follicular B-cell lymphoma with clarithromycin, prednisolone, and cyclophosphamide.

2. Repurposing Drugs in Oncology (ReDO)-clarithromycin as an anti-cancer agent.

3. Successful treatment of diffuse large B-cell lymphoma with clarithromycin and prednisolone.

4. Successful treatment of angioimmunoblastic T-cell lymphoma with clarithromycin.

5. A case of Waldenström's macroglobulinemia treated using clarithromycin and prednisolone.