OBJECTIVE: Several cutoff points of the homeostasis model assessment of insulin resistance (HOMA-IR; varying from 2.5 to 4.0) have been suggested for diagnosing IR in youth. In this study, we determined the distribution of the HOMA-IR in Mexican children and adolescents. DESIGN AND METHODS: A total of 6132 children and adolescents from San Luis Potosi, León, Queretaro, and Durango, which are cities in central and northern Mexico, were enrolled in a population-based cross-sectional study. Eligible participants were apparently healthy children and adolescents aged 6-18 years. Pregnancy and the presence of chronic illnesses were exclusion criteria. RESULTS: A total of 3701 (60.3%) girls and 2431 (39.7%) boys were included in this study. In the overall population, the mean body mass index, insulin levels, and fasting glucose levels were 21.8±1.3 kg/m(2), 7.1±3.2 μU/ml, and 86.2±10.0 mg/dl respectively. The concentrations of insulin and fasting glucose gradually increased from 6 to 12 years of age, whereas the concentrations tended to plateau in the 13- to 18-year-old population. The absolute mean of the HOMA-IR was 2.89±0.7. The HOMA-IR gradually increased with age and reached a plateau at 13 years of age. CONCLUSIONS: Because the insulin concentrations, glucose levels, and HOMA-IR exhibited a gradual increase with age that was not related to obesity, our results suggested that the evaluation of IR in children should be based on percentiles of the HOMA-IR rather than a dichotomous value derived from a single cutoff point.
OBJECTIVE: Several cutoff points of the homeostasis model assessment of insulin resistance (HOMA-IR; varying from 2.5 to 4.0) have been suggested for diagnosing IR in youth. In this study, we determined the distribution of the HOMA-IR in Mexican children and adolescents. DESIGN AND METHODS: A total of 6132 children and adolescents from San Luis Potosi, León, Queretaro, and Durango, which are cities in central and northern Mexico, were enrolled in a population-based cross-sectional study. Eligible participants were apparently healthy children and adolescents aged 6-18 years. Pregnancy and the presence of chronic illnesses were exclusion criteria. RESULTS: A total of 3701 (60.3%) girls and 2431 (39.7%) boys were included in this study. In the overall population, the mean body mass index, insulin levels, and fasting glucose levels were 21.8±1.3 kg/m(2), 7.1±3.2 μU/ml, and 86.2±10.0 mg/dl respectively. The concentrations of insulin and fasting glucose gradually increased from 6 to 12 years of age, whereas the concentrations tended to plateau in the 13- to 18-year-old population. The absolute mean of the HOMA-IR was 2.89±0.7. The HOMA-IR gradually increased with age and reached a plateau at 13 years of age. CONCLUSIONS: Because the insulin concentrations, glucose levels, and HOMA-IR exhibited a gradual increase with age that was not related to obesity, our results suggested that the evaluation of IR in children should be based on percentiles of the HOMA-IR rather than a dichotomous value derived from a single cutoff point.
Authors: Erika J Starks; J Patrick O'Grady; Siobhan M Hoscheidt; Annie M Racine; Cynthia M Carlsson; Henrik Zetterberg; Kaj Blennow; Ozioma C Okonkwo; Luigi Puglielli; Sanjay Asthana; N Maritza Dowling; Carey E Gleason; Rozalyn M Anderson; Nancy J Davenport-Sis; LeAnn M DeRungs; Mark A Sager; Sterling C Johnson; Barbara B Bendlin Journal: J Alzheimers Dis Date: 2015 Impact factor: 4.472
Authors: J Peplies; D Jiménez-Pavón; S C Savva; C Buck; K Günther; A Fraterman; P Russo; L Iacoviello; T Veidebaum; M Tornaritis; S De Henauw; S Mårild; D Molnár; L A Moreno; W Ahrens Journal: Int J Obes (Lond) Date: 2014-09 Impact factor: 5.095
Authors: Lourdes Barbosa-Cortés; Mardia López-Alarcón; Juan Manuel Mejía-Aranguré; Miguel Klünder-Klünder; María Del Carmen Rodríguez-Zepeda; Hugo Rivera-Márquez; Alan de la Vega-Martínez; Jorge Martin-Trejo; Juan Shum-Luis; Karina Solis-Labastida; Enrique López-Aguilar; Guadalupe Matute-González; Roberto Bernaldez-Rios Journal: BMC Cancer Date: 2017-02-13 Impact factor: 4.430