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Literature DB >> 220657

Cerebrospinal fluid cyclic AMP and acid monoamine metabolites following probenecid: studies in psychiatric patients.

Abstract

At probenecid levels greater than 10 microgram/ml, CSF cAMP was independent of CSF probenecid concentration. At these levels of probenecid, cAMP transport out of CSF is probably maximally blocked and cAMP levels reflect cAMP release into CSF. CSF cAMP was significantly higher in RDC-diagnosed schizophrenics than in other psychotics or depressives. A significant decrease in CSF cAMP was found in psychotic patients treated with chlorpromazine, No changes in CSF cAMP were observed in patients treated with tricyclic antidepressants or lithium.

Entities: Chemical Disease Gene Species

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Year: 1979 PMID： 220657 DOI： 10.1007/bf00426029

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

38 in total

1. Time-dependent effects of phenothiazines on dopamine turnover in psychiatric patients.

Authors: R M Post; F K Goodwin
Journal: Science Date: 1975-10-31 Impact factor: 47.728

2. Cyclic amp concentration and enzyme activities of cerebrospinal fluid in patients with epilepsy or central nervous system damage.

Authors: V V Myllylä; E R Heikkinen; H Vapaatalo; E Hokkanen
Journal: Eur Neurol Date: 1975 Impact factor: 1.710

3. Stimulation by dopamine of adenosine cyclic 3',5'-monophosphate formation in rat caudate nucleus: effect of lesions of the nigro-neostriatal pathway.

Authors: B K Krueger; J Forn; J R Walters; R H Roth; P Greengard
Journal: Mol Pharmacol Date: 1976-07 Impact factor: 4.436

4. Effects of probenecid and exercise on cerebrospinal-fluid cyclic A.M.P. in affective illness.

Authors: H Cramer; F K Goodwin; R M Post; W E Bunney
Journal: Lancet Date: 1972-06-17 Impact factor: 79.321

5. Effect of intravenously administered probenecid in humans on the levels of 5-hydroxyindoleacetic acid, homovanillic acid and 3-methoxy-4-hydroxy-phenylglycol in cerebrospinal fluid.

Authors: J Korf; H M van Praag; J B Sebens
Journal: Biochem Pharmacol Date: 1971-03 Impact factor: 5.858

6. Concentrations of 5-hydroxyindoleacetic acid and homovanillic acid in the cerebrospinal fluid after treatment with probenecid in patients with Parkinson's disease.

Authors: R Olsson; B E Roos
Journal: Nature Date: 1968-08-03 Impact factor: 49.962

7. Adenosine 3',5'-monophosphate in guinea pig cerebral cortical slices: effects of alpha- and beta-adrenergic agents, histamine, serotonin and adenosine.

Authors: J Schultz; J W Daly
Journal: J Neurochem Date: 1973-09 Impact factor: 5.372

Cerebrospinal fluid cyclic AMP and acid monoamine metabolites following probenecid: studies in psychiatric patients.

1. Time-dependent effects of phenothiazines on dopamine turnover in psychiatric patients.

2. Cyclic amp concentration and enzyme activities of cerebrospinal fluid in patients with epilepsy or central nervous system damage.

3. Stimulation by dopamine of adenosine cyclic 3',5'-monophosphate formation in rat caudate nucleus: effect of lesions of the nigro-neostriatal pathway.

4. Effects of probenecid and exercise on cerebrospinal-fluid cyclic A.M.P. in affective illness.

5. Effect of intravenously administered probenecid in humans on the levels of 5-hydroxyindoleacetic acid, homovanillic acid and 3-methoxy-4-hydroxy-phenylglycol in cerebrospinal fluid.

6. Concentrations of 5-hydroxyindoleacetic acid and homovanillic acid in the cerebrospinal fluid after treatment with probenecid in patients with Parkinson's disease.

7. Adenosine 3',5'-monophosphate in guinea pig cerebral cortical slices: effects of alpha- and beta-adrenergic agents, histamine, serotonin and adenosine.

8. Research diagnostic criteria: rationale and reliability.

9. CYCLIC AMP/*SECRETl cyclic AMP into push-pull perfusates in freely moving rats.

10. Postsynaptic supersensitivity in schizophrenia.

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