Literature DB >> 22064667

Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society.

H F Escobar-Morreale1, E Carmina, D Dewailly, A Gambineri, F Kelestimur, P Moghetti, M Pugeat, J Qiao, C N Wijeyaratne, S F Witchel, R J Norman.   

Abstract

BACKGROUND: Hirsutism, defined by the presence of excessive terminal hair in androgen-sensitive areas of the female body, is one of the most common disorders in women during reproductive age.
METHODS: We conducted a systematic review and critical assessment of the available evidence pertaining to the epidemiology, pathophysiology, diagnosis and management of hirsutism.
RESULTS: The prevalence of hirsutism is ~10% in most populations, with the important exception of Far-East Asian women who present hirsutism less frequently. Although usually caused by relatively benign functional conditions, with the polycystic ovary syndrome leading the list of the most frequent etiologies, hirsutism may be the presenting symptom of a life-threatening tumor requiring immediate intervention.
CONCLUSIONS: Following evidence-based diagnostic and treatment strategies that address not only the amelioration of hirsutism but also the treatment of the underlying etiology is essential for the proper management of affected women, especially considering that hirsutism is, in most cases, a chronic disorder needing long-term follow-up. Accordingly, we provide evidence-based guidelines for the etiological diagnosis and for the management of this frequent medical complaint.

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Year:  2011        PMID: 22064667     DOI: 10.1093/humupd/dmr042

Source DB:  PubMed          Journal:  Hum Reprod Update        ISSN: 1355-4786            Impact factor:   15.610


  82 in total

1.  For what reasons should metformin be used in the management of polycystic ovary syndrome?

Authors:  P Moghetti
Journal:  J Endocrinol Invest       Date:  2011-12-21       Impact factor: 4.256

2.  Approach to the management of idiopathic hirsutism.

Authors:  Milena Markovski; Jill Hall; Margaret Jin; Tessa Laubscher; Loren Regier
Journal:  Can Fam Physician       Date:  2012-02       Impact factor: 3.275

Review 3.  Emerging concepts about prenatal genesis, aberrant metabolism and treatment paradigms in polycystic ovary syndrome.

Authors:  Selma F Witchel; Sergio E Recabarren; Frank González; Evanthia Diamanti-Kandarakis; Kai I Cheang; Antoni J Duleba; Richard S Legro; Roy Homburg; Renato Pasquali; Rogerio A Lobo; Christos C Zouboulis; Fahrettin Kelestimur; Franca Fruzzetti; Walter Futterweit; Robert J Norman; David H Abbott
Journal:  Endocrine       Date:  2012-06-04       Impact factor: 3.633

4.  Flutamide: hirsutism in women.

Authors:  Joyce A Generali; Dennis J Cada
Journal:  Hosp Pharm       Date:  2014-06

Review 5.  Polycystic ovary syndrome in adolescence: diagnostic and therapeutic strategies.

Authors:  Manmohan K Kamboj; Andrea E Bonny
Journal:  Transl Pediatr       Date:  2017-10

6.  Biochemical hyperandrogenism is associated with metabolic syndrome independently of adiposity and insulin resistance in Romanian polycystic ovary syndrome patients.

Authors:  Alice Albu; Serban Radian; Simona Fica; Carmen Gabriela Barbu
Journal:  Endocrine       Date:  2014-07-15       Impact factor: 3.633

7.  How to manage the reproductive issues of PCOS: a 2015 integrated endocrinological and gynecological consensus statement of the Italian Society of Endocrinology.

Authors:  P Moghetti; E Carmina; V De Leo; A Lanzone; F Orio; R Pasquali; V Toscano
Journal:  J Endocrinol Invest       Date:  2015-04-03       Impact factor: 4.256

Review 8.  New perspectives on the definition and management of polycystic ovary syndrome.

Authors:  R Pasquali; A Gambineri
Journal:  J Endocrinol Invest       Date:  2018-01-23       Impact factor: 4.256

9.  Delayed presentation of a virilising, pure testosterone-secreting adrenocortical carcinoma with coexistent composite myelolipoma and a venous thrombus extending to the heart.

Authors:  Rakesh M Sharma; Sanjay Sinha; Hari B Kishan; Michelle De Padua
Journal:  BMJ Case Rep       Date:  2018-01-23

10.  Increased expression of kindlin 2 in luteinized granulosa cells correlates with androgen receptor level in patients with polycystic ovary syndrome having hyperandrogenemia.

Authors:  Mei Yang; Juan Du; Danyu Lu; Caixia Ren; Huan Shen; Jie Qiao; Xi Chen; Hongquan Zhang
Journal:  Reprod Sci       Date:  2013-12-13       Impact factor: 3.060

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