Literature DB >> 22064536

Distribution of spontaneous gyrA mutations in 97 fluoroquinolone-resistant Helicobacter pylori isolates collected in France.

Magali Garcia1, Josette Raymond, Martine Garnier, Julie Cremniter, Christophe Burucoa.   

Abstract

We determined the prevalence of gyrA mutations conferring fluoroquinolone resistance in 97 Helicobacter pylori isolates collected in France from 2007 to 2010. Ninety-four harbored one or two mutations already found in the quinolone resistance determining region (QRDR) of gyrA (for T87I, n = 23; for N87K, n = 32; for D91N, n = 30; for D91G, n = 7; for D91Y, n = 6), 2 harbored a mutation never previously described (D91H and A88P), and one strain was resistant (ciprofloxacin MIC of 8 mg/liter) without a detected mutation conferring this resistance in gyrA or gyrB genes.

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Year:  2011        PMID： 22064536      PMCID： PMC3256052          DOI： 10.1128/AAC.05243-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

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Authors:  F Mégraud
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Authors:  B Grignon; J Tankovic; F Mégraud; Y Glupczynski; M O Husson; M C Conroy; J P Emond; J Loulergue; J Raymond; J L Fauchère
Journal:  Microb Drug Resist       Date:  2002       Impact factor: 3.431

4.  High level of antimicrobial resistance in French Helicobacter pylori isolates.

Authors:  Josette Raymond; Dominique Lamarque; Nicolas Kalach; Stanislas Chaussade; Christophe Burucoa
Journal:  Helicobacter       Date:  2010-02       Impact factor: 5.753

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Journal:  J Med Microbiol       Date:  2004-10       Impact factor: 2.472

7.  Nucleotide sequence of the gyrA gene and characterization of ciprofloxacin-resistant mutants of Helicobacter pylori.

Authors:  R A Moore; B Beckthold; S Wong; A Kureishi; L E Bryan
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

8.  Rapid detection of point mutations in the gyrA gene of Helicobacter pylori conferring resistance to ciprofloxacin by a fluorescence resonance energy transfer-based real-time PCR approach.

Authors:  Erik Glocker; Manfred Kist
Journal:  J Clin Microbiol       Date:  2004-05       Impact factor: 5.948

9.  Mutations in topoisomerase genes of fluoroquinolone-resistant salmonellae in Hong Kong.

Authors:  J M Ling; E W Chan; A W Lam; A F Cheng
Journal:  Antimicrob Agents Chemother       Date:  2003-11       Impact factor: 5.191

10.  Single and double mutations in gyrA but not in gyrB are associated with low- and high-level fluoroquinolone resistance in Helicobacter pylori.

Authors:  Jacques Tankovic; Christine Lascols; Quentin Sculo; Jean-Claude Petit; Claude-James Soussy
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191
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  17 in total

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6.  The clinical and bacteriological factors for optimal levofloxacin-containing triple therapy in second-line Helicobacter pylori eradication.

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8.  Current status of Helicobacter pylori resistance to Clarithromycin and Levofloxacin in Malaysia-findings from a molecular based study.

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9.  Molecular Detection of Antibiotic Resistance in South African Isolates of Helicobacter pylori.

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10.  Functional and molecular surveillance of Helicobacter pylori antibiotic resistance in Kuala Lumpur.

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