Literature DB >> 22057636

Outcome of pregnancy in type 1 diabetes mellitus (T1DMP): results from combined diabetes-obstetrical clinics in Dublin in three university teaching hospitals (1995-2006).

R Al-Agha1, R G Firth, M Byrne, S Murray, S Daly, M Foley, S C Smith, B T Kinsley.   

Abstract

OBJECTIVE: To compare the pregnancy outcomes in all T1DMP attending at combined (diabetes-obstetric) outpatients clinics in three university teaching hospitals in Dublin from 1995 to 2006 with a non-diabetic control population (C) attending at antenatal outpatient clinics at the same hospitals over the same period.
METHODS: T1DMP (n = 600) were compared with control non-diabetic pregnancies (n = 142,498).
RESULTS: The spontaneous abortion rate was 15% in T1DMP versus 8% in C (p < 0.0001). Perinatal mortality rate was 3.3% in T1DMP compared to 0.9% in C (p < 0.001). The incidence of foetal macrosomia was 29% in T1DMP versus 16% in C (p < 0.001).
CONCLUSIONS: Pregnancy outcomes in T1DMP remain worse than in the general population despite management of T1DMP in combined obstetric/diabetes clinics in a single centre using similar management protocols. These outcomes in our study population of T1DMP in Dublin appear better than some previously reported studies.

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Year:  2011        PMID: 22057636     DOI: 10.1007/s11845-011-0781-6

Source DB:  PubMed          Journal:  Ir J Med Sci        ISSN: 0021-1265            Impact factor:   1.568


  16 in total

1.  The effects of first-trimester diabetes control on the incidence of macrosomia.

Authors:  E Rey; C Attié; A Bonin
Journal:  Am J Obstet Gynecol       Date:  1999-07       Impact factor: 8.661

2.  Outcome of pregnancy in diabetic women in northeast England and in Norway, 1994-7.

Authors:  G Hawthorne; L M Irgens; R T Lie
Journal:  BMJ       Date:  2000-09-23

3.  Association between outcome of pregnancy and glycaemic control in early pregnancy in type 1 diabetes: population based study.

Authors:  Rosemary Temple; Vivien Aldridge; Richard Greenwood; Philip Heyburn; Michael Sampson; Katharine Stanley
Journal:  BMJ       Date:  2002-11-30

4.  The confidential enquiry into maternal and child health (CEMACH).

Authors:  A M Weindling
Journal:  Arch Dis Child       Date:  2003-12       Impact factor: 3.791

5.  HbA1c in healthy, pregnant women.

Authors:  J K Radder; J van Roosmalen
Journal:  Neth J Med       Date:  2005 Jul-Aug       Impact factor: 1.422

6.  Outcomes in type 1 diabetic pregnancies: a nationwide, population-based study.

Authors:  Dorte M Jensen; Peter Damm; Lars Moelsted-Pedersen; Per Ovesen; Jes G Westergaard; Margrethe Moeller; Henning Beck-Nielsen
Journal:  Diabetes Care       Date:  2004-12       Impact factor: 19.112

7.  Audit on stillbirths in women with pregestational type 1 diabetes.

Authors:  Jeannet Lauenborg; Elisabeth Mathiesen; Per Ovesen; Jes G Westergaard; Pia Ekbom; Lars Mølsted-Pedersen; Peter Damm
Journal:  Diabetes Care       Date:  2003-05       Impact factor: 19.112

8.  ATLANTIC DIP: pregnancy outcome for women with pregestational diabetes along the Irish Atlantic seaboard.

Authors:  Fidelma P Dunne; Gloria Avalos; Meave Durkan; Yvonne Mitchell; Therese Gallacher; Marita Keenan; Marie Hogan; Louise A Carmody; Geraldine Gaffney
Journal:  Diabetes Care       Date:  2009-07       Impact factor: 17.152

9.  Glycemic thresholds for spontaneous abortion and congenital malformations in insulin-dependent diabetes mellitus.

Authors:  B Rosenn; M Miodovnik; C A Combs; J Khoury; T A Siddiqi
Journal:  Obstet Gynecol       Date:  1994-10       Impact factor: 7.661

10.  French multicentric survey of outcome of pregnancy in women with pregestational diabetes.

Authors:  Pierre Boulot; Nathalie Chabbert-Buffet; Claude d'Ercole; Michele Floriot; Pierre Fontaine; Alain Fournier; Jean Yves Gillet; Henri Gin; Sylvie Grandperret-Vauthier; Ann Marie Geudj; Brigette Guionnet; Sylvie Hauguel-de-Mouzon; Sylvie Hieronimus; Mederic Hoffet; Dominique Jullien; Marie Françoise Lamotte; Veronique Lejeune; Jacques Lepercq; Françoise Lorenzi; Pierre Mares; Alain Miton; Alfred Penfornis; Brigitte Pfister; Eric Renard; Michel Rodier; Philippe Roth; Guy-Alain Sery; José Timsit; Anne Sylvie Valat; Anne Vambergue; Odile Verier-Mine
Journal:  Diabetes Care       Date:  2003-11       Impact factor: 19.112

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  6 in total

1.  Risk of birth defects associated with maternal pregestational diabetes.

Authors:  Marco Vinceti; Carlotta Malagoli; Kenneth J Rothman; Rossella Rodolfi; Gianni Astolfi; Elisa Calzolari; Aurora Puccini; Marco Bertolotti; Mark Lunt; Luisa Paterlini; Mariella Martini; Fausto Nicolini
Journal:  Eur J Epidemiol       Date:  2014-05-27       Impact factor: 8.082

2.  Hyperglycemia induces embryopathy, even in the absence of systemic maternal diabetes: an in vivo test of the fuel mediated teratogenesis hypothesis.

Authors:  Michelle L Baack; Chunlin Wang; Shanming Hu; Jeffrey L Segar; Andrew W Norris
Journal:  Reprod Toxicol       Date:  2014-04-08       Impact factor: 3.143

Review 3.  Endocrine autoimmune diseases and female infertility.

Authors:  Aritro Sen; Vitaly A Kushnir; David H Barad; Norbert Gleicher
Journal:  Nat Rev Endocrinol       Date:  2013-11-05       Impact factor: 43.330

4.  Race/ethnicity, educational attainment, and pregnancy complications in New York City women with pre-existing diabetes.

Authors:  Tamarra James-Todd; Teresa Janevic; Florence M Brown; David A Savitz
Journal:  Paediatr Perinat Epidemiol       Date:  2013-12-20       Impact factor: 3.980

5.  Cardiomyopathy in offspring of pregestational diabetic mouse pregnancy.

Authors:  Daniel Dowling; Niamh Corrigan; Stephen Horgan; Chris J Watson; John Baugh; Paul Downey; Fionnuala M McAuliffe
Journal:  J Diabetes Res       Date:  2014-06-26       Impact factor: 4.011

Review 6.  Management of Type 1 Diabetes in Pregnancy.

Authors:  Anna Z Feldman; Florence M Brown
Journal:  Curr Diab Rep       Date:  2016-08       Impact factor: 4.810

  6 in total

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