Literature DB >> 22057567

Measurement of proton leak and electron leak in isolated mitochondria.

Charles Affourtit1, Casey L Quinlan, Martin D Brand.   

Abstract

Oxidative phosphorylation is an important energy-conserving mechanism coupling mitochondrial electron transfer to ATP synthesis. Coupling between respiration and phosphorylation is not fully efficient due to proton and electron leaks. In this chapter, methods are presented to measure proton and electron leak activities in isolated mitochondria. The relative strength of a modular kinetic approach to probe oxidative phosphorylation is emphasised.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22057567     DOI： 10.1007/978-1-61779-382-0_11

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  34 in total

Review 1.  Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through cGMP-Dependent Mechanisms.

Authors:  Younghye Moon; Jordan E Balke; Derik Madorma; Michael P Siegel; Gary Knowels; Peter Brouckaert; Emmanuel S Buys; David J Marcinek; Justin M Percival
Journal:  Antioxid Redox Signal       Date:  2016-08-17       Impact factor: 8.401

2.  Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening.

Authors:  Adam L Orr; Deepthi Ashok; Melissa R Sarantos; Tong Shi; Robert E Hughes; Martin D Brand
Journal:  Free Radic Biol Med       Date:  2013-08-27       Impact factor: 7.376

3.  Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.

Authors:  Kelsey H Fisher-Wellman; Chien-Te Lin; Terence E Ryan; Lauren R Reese; Laura A A Gilliam; Brook L Cathey; Daniel S Lark; Cody D Smith; Deborah M Muoio; P Darrell Neufer
Journal:  Biochem J       Date:  2015-04-15       Impact factor: 3.857

Review 4.  Physiological strategies during animal diapause: lessons from brine shrimp and annual killifish.

Authors:  Jason E Podrabsky; Steven C Hand
Journal:  J Exp Biol       Date:  2015-06       Impact factor: 3.312

5.  Uncoupling protein 1 controls reactive oxygen species in brown adipose tissue.

Authors:  Martin Jastroch
Journal:  Proc Natl Acad Sci U S A       Date:  2017-07-14       Impact factor: 11.205

6.  Positive Feedback Amplifies the Response of Mitochondrial Membrane Potential to Glucose Concentration in Clonal Pancreatic Beta Cells.

Authors:  Akos A Gerencser; Shona A Mookerjee; Martin Jastroch; Martin D Brand
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2016-10-20       Impact factor: 5.187

7.  Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions.

Authors:  Casey L Quinlan; Adam L Orr; Irina V Perevoshchikova; Jason R Treberg; Brian A Ackrell; Martin D Brand
Journal:  J Biol Chem       Date:  2012-06-11       Impact factor: 5.157

8.  Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.

Authors:  Martin D Brand; Renata L S Goncalves; Adam L Orr; Leonardo Vargas; Akos A Gerencser; Martin Borch Jensen; Yves T Wang; Simon Melov; Carolina N Turk; Jason T Matzen; Victoria J Dardov; H Michael Petrassi; Shelly L Meeusen; Irina V Perevoshchikova; Heinrich Jasper; Paul S Brookes; Edward K Ainscow
Journal:  Cell Metab       Date:  2016-09-22       Impact factor: 27.287

9.  Increased production of mitochondrial reactive oxygen species and reduced adult life span in an insecticide-resistant strain of Anopheles gambiae.

Authors:  D Otali; R J Novak; W Wan; S Bu; D R Moellering; M De Luca
Journal:  Bull Entomol Res       Date:  2014-02-21       Impact factor: 1.750

10.  Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria.

Authors:  Irina V Perevoshchikova; Casey L Quinlan; Adam L Orr; Akos A Gerencser; Martin D Brand
Journal:  Free Radic Biol Med       Date:  2013-04-11       Impact factor: 7.376
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.