| Literature DB >> 22057127 |
Genna M Luciani1, Lilia Magomedova, Rachel Puckrin, Malene L Urbanus, Iain M Wallace, Guri Giaever, Corey Nislow, Carolyn L Cummins, Peter J Roy.
Abstract
The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematode Caenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals.Entities:
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Year: 2011 PMID： 22057127 DOI： 10.1038/nchembio.698
Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040