| Literature DB >> 22056746 |
Thomas M Kirrane1, Stephen J Boyer, Jennifer Burke, Xin Guo, Roger J Snow, Lida Soleymanzadeh, Alan Swinamer, Yunlong Zhang, Jeffery B Madwed, Mohammed Kashem, Stanley Kugler, Margaret M O'Neill.
Abstract
A series of inhibitors for the 90 kDa ribosomal S6 kinase (RSK) based on an 1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide scaffold were optimized for cellular potency and kinase selectivity. This led to the identification of compound 24, BIX 02565, an attractive candidate for use in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure.Entities:
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Year: 2011 PMID： 22056746 DOI： 10.1016/j.bmcl.2011.10.029
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823