Literature DB >> 22056445

Effective cytochrome P450 (CYP) inhibitor isolated from thyme (Thymus saturoides) purchased from a Japanese market.

Zeineb Brahmi1, Hitomi Niwa, Mio Yamasato, Sakurako Shigeto, Yuna Kusakari, Kouichi Sugaya, Jun-ichi Onose, Naoki Abe.   

Abstract

A highly polymethylated flavone that effectively inhibited cytochrome P450s (CYPs) 1A2 and 3A4 (IC(50) = 2.41 and 1.71 µM) in vitro was isolated from thyme leaves (Thymus saturoides) purchased from a Japanese market. Its structure was spectroscopically identified as 4',5-dihydroxy-3',6,7,8-tetramethoxy flavone (8-methoxycirsilineol, 1). This is the first report describing a strong inhibitor of CYP1A2 and 3A4 isolated from Thymus saturoides.

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Year:  2011        PMID： 22056445     DOI： 10.1271/bbb.110328

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  2 in total

Review 1.  Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals.

Authors:  Josefina Gómez-Garduño; Renato León-Rodríguez; Radamés Alemón-Medina; Beatriz E Pérez-Guillé; Rosa E Soriano-Rosales; Ailema González-Ortiz; Juan L Chávez-Pacheco; Edelmira Solorio-López; Paola Fernandez-Pérez; Liliana Rivera-Espinosa
Journal:  Dose Response       Date:  2022-09-21       Impact factor: 2.623

2.  Breast cancer cell line toxicity of a flavonoid isolated from Baccharis densiflora.

Authors:  Wendy Soria Sotillo; Santiago Tarqui; Xiaoli Huang; Giovanna Almanza; Stina Oredsson
Journal:  BMC Complement Med Ther       Date:  2021-07-02
  2 in total

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