Literature DB >> 22056248

Neonatal hypoxia-ischemia induces sex-related changes in rat brain mitochondria.

Simone N Weis1, Leticia F Pettenuzzo, Rachel Krolow, Lauren M Valentim, Carina S Mota, Carla Dalmaz, Angela T S Wyse, Carlos Alexandre Netto.   

Abstract

The effects of neonatal hypoxia-ischemia (HI) on energy metabolism in male and female rats were investigated, testing the hypothesis that HI-induced brain mitochondrial dysfunction could present in a dimorphic pattern. Impairment in electron transport chain complex activities at 2 and 18 h after HI was observed in cortex and hippocampus in rats of both sexes, with females presenting an overall activity higher than that of males. Females also showed loss of mitochondrial mass and membrane potential 18 h after HI, while males were only slightly affected. These findings suggest a dimorphism in mitochondrial dysfunction and provide information that may lead to new neuroprotection strategies. Copyright Â
© 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

Entities:  

Mesh：

Year:  2011        PMID： 22056248     DOI： 10.1016/j.mito.2011.10.002

Source DB:  PubMed          Journal:  Mitochondrion        ISSN： 1567-7249            Impact factor:   4.160


  19 in total

1.  Chronic Stress Causes Sex-Specific and Structure-Specific Alterations in Mitochondrial Respiratory Chain Activity in Rat Brain.

Authors:  Carina de Souza Mota; Simone Nardin Weis; Roberto Farina Almeida; Carla Dalmaz; Fátima Therezinha Costa Guma; Letícia Ferreira Pettenuzzo
Journal:  Neurochem Res       Date:  2017-09-14       Impact factor: 3.996

2.  Administration of Huperzia quadrifariata Extract, a Cholinesterase Inhibitory Alkaloid Mixture, has Neuroprotective Effects in a Rat Model of Cerebral Hypoxia-Ischemia.

Authors:  F K Odorcyk; E F Sanches; F C Nicola; J Moraes; L F Pettenuzzo; J Kolling; C Siebert; A Longoni; E L Konrath; A Wyse; C A Netto
Journal:  Neurochem Res       Date:  2016-11-24       Impact factor: 3.996

3.  Sex-specific effects of N-acetylcysteine in neonatal rats treated with hypothermia after severe hypoxia-ischemia.

Authors:  Xingju Nie; Danielle W Lowe; Laura Grace Rollins; Jessica Bentzley; Jamie L Fraser; Renee Martin; Inderjit Singh; Dorothea Jenkins
Journal:  Neurosci Res       Date:  2016-02-03       Impact factor: 3.304

Review 4.  Sex differences in mitochondrial (dys)function: Implications for neuroprotection.

Authors:  Tyler G Demarest; Margaret M McCarthy
Journal:  J Bioenerg Biomembr       Date:  2014-10-08       Impact factor: 2.945

5.  In utero exposure to transient ischemia-hypoxemia promotes long-term neurodevelopmental abnormalities in male rat offspring.

Authors:  Arvind Palanisamy; Tusar Giri; Jia Jiang; Annie Bice; James D Quirk; Sara B Conyers; Susan E Maloney; Nandini Raghuraman; Adam Q Bauer; Joel R Garbow; David F Wozniak
Journal:  JCI Insight       Date:  2020-05-21

6.  Neuroprotective Effects of Acetyl-L-Carnitine on Neonatal Hypoxia Ischemia-Induced Brain Injury in Rats.

Authors:  Shiyu Tang; Su Xu; Xin Lu; Rao P Gullapalli; Mary C McKenna; Jaylyn Waddell
Journal:  Dev Neurosci       Date:  2017-02-23       Impact factor: 2.984

7.  Effect of a trans fatty acid-enriched diet on mitochondrial, inflammatory, and oxidative stress parameters in the cortex and hippocampus of Wistar rats.

Authors:  Rafael Longhi; Roberto Farina Almeida; Leticia Ferreira Pettenuzzo; Débora Guerini Souza; Letiane Machado; André Quincozes-Santos; Diogo Onofre Souza
Journal:  Eur J Nutr       Date:  2017-05-31       Impact factor: 5.614

8.  Sex-dependent mitochondrial respiratory impairment and oxidative stress in a rat model of neonatal hypoxic-ischemic encephalopathy.

Authors:  Tyler G Demarest; Rosemary A Schuh; Jaylyn Waddell; Mary C McKenna; Gary Fiskum
Journal:  J Neurochem       Date:  2016-05-06       Impact factor: 5.372

9.  Mitochondrial and Oxidative Stress Aspects in Hippocampus of Rats Submitted to Dietary n-3 Polyunsaturated Fatty Acid Deficiency After Exposure to Early Stress.

Authors:  Charles Francisco Ferreira; Juliana Rombaldi Bernardi; Diego Carrilho da Silva; Natividade de Sá Couto-Pereira; Carina de Souza Mota; Rachel Krolow; Simone Nardin Weis; Letícia Pettenuzzo; Flávio Kapczinski; Patrícia Pelufo Silveira; Carla Dalmaz
Journal:  Neurochem Res       Date:  2015-08-01       Impact factor: 3.996

Review 10.  Sex and steroid hormones in early brain injury.

Authors:  Joseph Nuñez
Journal:  Rev Endocr Metab Disord       Date:  2012-09       Impact factor: 6.514
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