OBJECTIVE: To determine the proportion and type of renal anomalies that occur in children born with classic bladder exstrophy. MATERIAL AND METHODS: All patients in a database of 1044 patients with the bladder exstrophy-epispadias-cloacal exstrophy complex were reviewed. Those with classic bladder exstrophy had their complete medical records reviewed and children with radiographic evidence of congenital renal anomalies were identified and characterized. RESULTS: A total of 674 patients were identified with classic bladder exstrophy, of whom 462 had renal ultrasounds at the authors' institution. In this population, 13/462 (2.8%) had concomitant renal anomalies. The most common malformation was a duplicated collecting system in 6 patients. Hypoplastic or absent kidneys were present in 3 patients, pelvic kidney in 2, ureteropelvic junction obstruction in 1, and multicystic dysplastic kidney in 1 patient. CONCLUSION: Isolated renal anomalies occur at a rate of 2.8% in children born with classic bladder exstrophy. Although uncommon in this rare birth defect, anatomic understanding of the entire genitourinary system is critical for operative planning and long-term follow-up of patients with bladder exstrophy.
OBJECTIVE: To determine the proportion and type of renal anomalies that occur in children born with classic bladder exstrophy. MATERIAL AND METHODS: All patients in a database of 1044 patients with the bladder exstrophy-epispadias-cloacal exstrophy complex were reviewed. Those with classic bladder exstrophy had their complete medical records reviewed and children with radiographic evidence of congenital renal anomalies were identified and characterized. RESULTS: A total of 674 patients were identified with classic bladder exstrophy, of whom 462 had renal ultrasounds at the authors' institution. In this population, 13/462 (2.8%) had concomitant renal anomalies. The most common malformation was a duplicated collecting system in 6 patients. Hypoplastic or absent kidneys were present in 3 patients, pelvic kidney in 2, ureteropelvic junction obstruction in 1, and multicystic dysplastic kidney in 1 patient. CONCLUSION: Isolated renal anomalies occur at a rate of 2.8% in children born with classic bladder exstrophy. Although uncommon in this rare birth defect, anatomic understanding of the entire genitourinary system is critical for operative planning and long-term follow-up of patients with bladder exstrophy.
Authors: Johanna Magdalena Rieke; Rong Zhang; Doreen Braun; Öznur Yilmaz; Anna S Japp; Filipa M Lopes; Michael Pleschka; Alina C Hilger; Sophia Schneider; William G Newman; Glenda M Beaman; Agneta Nordenskjöld; Anne-Karoline Ebert; Martin Promm; Wolfgang H Rösch; Raimund Stein; Karin Hirsch; Frank-Mattias Schäfer; Eberhard Schmiedeke; Thomas M Boemers; Martin Lacher; Dietrich Kluth; Jan-Hendrik Gosemann; Magnus Anderberg; Gillian Barker; Gundela Holmdahl; Göran Läckgren; David Keene; Raimondo M Cervellione; Elisa Giorgio; Massimo Di Grazia; Wouter F J Feitz; Carlo L M Marcelis; Iris A L M Van Rooij; Arend Bökenkamp; Goedele M A Beckers; Catherine E Keegan; Amit Sharma; Tikam Chand Dakal; Lars Wittler; Phillip Grote; Nadine Zwink; Ekkehart Jenetzky; Alfredo Brusco; Holger Thiele; Michael Ludwig; Ulrich Schweizer; Adrian S Woolf; Benjamin Odermatt; Heiko Reutter Journal: Front Cell Dev Biol Date: 2020-08-07