| Literature DB >> 22055504 |
Silvie Timmers1,2, Ellen Konings2, Lena Bilet2, Riekelt H Houtkooper3, Tineke van de Weijer2, Gijs H Goossens2, Joris Hoeks2, Sophie van der Krieken2, Dongryeol Ryu3, Sander Kersten4, Esther Moonen-Kornips2, Matthijs K C Hesselink5, Iris Kunz6, Vera B Schrauwen-Hinderling7, Ellen Blaak2, Johan Auwerx3, Patrick Schrauwen1,2.
Abstract
Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1α protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.Entities:
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Year: 2011 PMID： 22055504 PMCID： PMC3880862 DOI： 10.1016/j.cmet.2011.10.002
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287