Literature DB >> 220539

Local aggregation of hormone-receptor complexes is required for activation by epidermal growth factor.

Y Schechter, L Hernaez, J Schlessinger, P Cuatrecasas.   

Abstract

An analogue of epidermal growth factor (EGF) which is virtually devoid of biological activity retains receptor binding activity but cannot form cell surface clusters or patches. Bivalent anti-EGF antibodies restore both bioactivity and patch formation. The sensitivity of fibroblasts to native EGF can also be enhanced greatly by these antibodies, especially in hormone-resistant cell lines.

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Year:  1979        PMID： 220539     DOI： 10.1038/278835a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  46 in total

Review 1.  Monoclonal antibodies to epidermal growth factor receptors in studies of receptor structure and function.

Authors:  T Kawamoto; G H Sato; K Takahashi; M Nishi; S Taniguchi; J D Sato
Journal:  Cytotechnology       Date:  1990-05       Impact factor: 2.058

2.  Stabilized complexes of epidermal growth factor and its receptor on the cell surface stimulate RNA synthesis but not mitogenesis.

Authors:  E M Wakshull; W Wharton
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

Review 3.  Mechanisms of receptor-mediated transmembrane signalling.

Authors:  M D Hollenberg
Journal:  Experientia       Date:  1986-07-15

4.  Quantitative characterization of the large-scale association of ErbB1 and ErbB2 by flow cytometric homo-FRET measurements.

Authors:  Agnes Szabó; Gábor Horváth; János Szöllosi; Peter Nagy
Journal:  Biophys J       Date:  2008-05-16       Impact factor: 4.033

5.  Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression.

Authors:  I Lax; F Bellot; A M Honegger; A Schmidt; A Ullrich; D Givol; J Schlessinger
Journal:  Cell Regul       Date:  1990-01

6.  Orientation and patching of the latent infection membrane protein encoded by Epstein-Barr virus.

Authors:  D Liebowitz; D Wang; E Kieff
Journal:  J Virol       Date:  1986-04       Impact factor: 5.103

7.  Antitubulin agents enhance the stimulation of DNA synthesis by polypeptide growth factors in 3T3 mouse fibroblasts.

Authors:  M Friedkin; A Legg; E Rozengurt
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

8.  Virus-receptor interaction in the adenovirus system: characterization of the positive cooperative binding of virions on HeLa cells.

Authors:  R Persson; C Wohlfart; U Svensson; E Everitt
Journal:  J Virol       Date:  1985-04       Impact factor: 5.103

9.  Lysomotropic amines cause intracellular accumulation of receptors for epidermal growth factor.

Authors:  A C King; L Hernaez-Davis; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

10.  Receptor-mediated internalization of fluorescent gonadotropin-releasing hormone by pituitary gonadotropes.

Authors:  E Hazum; P Cuatrecasas; J Marian; P M Conn
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205
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