Literature DB >> 2205376

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

A E Pegg1.   

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Year:  1990        PMID: 2205376

Source DB:  PubMed          Journal:  Cancer Res        ISSN: 0008-5472            Impact factor:   12.701


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  188 in total

1.  Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene.

Authors:  G S Watts; R O Pieper; J F Costello; Y M Peng; W S Dalton; B W Futscher
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

2.  Promoter hypermethylation of RASSF1A, MGMT, and HIC-1 genes in benign and malignant colorectal tumors.

Authors:  Hamdy E Abouzeid; Abdel Meguid Kassem; Abdel Hady Abdel Wahab; Hatem A El-mezayen; Hayaat Sharad; Shaimaa Abdel Rahman
Journal:  Tumour Biol       Date:  2011-01-28

3.  Relationship between O6-alkylguanine-DNA alkyltransferase activity and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutation, transformation, and cytotoxicity in C3H/10T1/2 cells expressing exogenous alkyltransferase genes.

Authors:  E von Hofe; L Fairbairn; G P Margison
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

4.  Notes on the use of in vitro systems to investigate the activity and the mechanism of action of antineoplastic agents.

Authors:  M D'Incalci; G Balconi; M Broggini; F Civoli; E Erba; E Fabbri; F Morali; P Taverna
Journal:  Cytotechnology       Date:  1991-02       Impact factor: 2.058

5.  4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine.

Authors:  Rui Zhu; Mao-Chin Liu; Mei-Zhen Luo; Philip G Penketh; Raymond P Baumann; Krishnamurthy Shyam; Alan C Sartorelli
Journal:  J Med Chem       Date:  2011-10-17       Impact factor: 7.446

Review 6.  Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.

Authors:  P Karran; M Bignami
Journal:  Nucleic Acids Res       Date:  1992-06-25       Impact factor: 16.971

7.  O6-Alkylguanine-DNA alkyltransferase content in synchronised human cancer cells.

Authors:  P Coccia; S Sen; E Erba; P Pagani; C Marinello; M D'Incalci
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

Review 8.  Insight into the cooperative DNA binding of the O⁶-alkylguanine DNA alkyltransferase.

Authors:  Ingrid Tessmer; Michael G Fried
Journal:  DNA Repair (Amst)       Date:  2014-02-16

9.  Genotoxic and cytotoxic effects of 4-aroyl-1-nitrosohydrazine-carboxamides on O6-alkylguanine-DNA alkyltransferase-positive and -negative human cell lines.

Authors:  C Schell; O Lantermann; W Popp; C Vahrenholz; J Thomale; R Gugova; E Golovinsky; K Norpoth
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

10.  Inhibition of O6-alkylguanine-DNA alkyltransferase in animal and human ovarian tumor cell lines by O6-benzylguanine and sensitization to BCNU.

Authors:  A Magull-Seltenreich; W J Zeller
Journal:  Cancer Chemother Pharmacol       Date:  1995       Impact factor: 3.333

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