Literature DB >> 22053051

RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing.

Jing-Ping Hsin1, Amit Sheth, James L Manley.   

Abstract

The RNA polymerase II (RNAP II) largest subunit contains a C-terminal domain (CTD) with up to 52 Tyr(1)-Ser(2)-Pro(3)-Thr(4)-Ser(5)-Pro(6)-Ser(7) consensus repeats. Serines 2, 5, and 7 are known to be phosphorylated, and these modifications help to orchestrate the interplay between transcription and processing of messenger RNA (mRNA) precursors. Here, we provide evidence that phosphorylation of CTD Thr(4) residues is required specifically for histone mRNA 3' end processing, functioning to facilitate recruitment of 3' processing factors to histone genes. Like Ser(2), Thr(4) phosphorylation requires the CTD kinase CDK9 and is evolutionarily conserved from yeast to human. Our data thus illustrate how a CTD modification can play a highly specific role in facilitating efficient gene expression.

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Year:  2011        PMID： 22053051      PMCID： PMC3678764          DOI： 10.1126/science.1206034

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  21 in total

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Authors:  S H Chao; D H Price
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5.  Level of the RNA polymerase II in the fission yeast stays constant but phosphorylation of its carboxyl terminal domain varies depending on the phase and rate of cell growth.

Authors:  Hitomi Sakurai; Akira Ishihama
Journal:  Genes Cells       Date:  2002-03       Impact factor: 1.891

6.  Calcium-dependent immediate-early gene induction in lymphocytes is negatively regulated by p21Ha-ras.

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Journal:  Mol Cell Biol       Date:  1996-11       Impact factor: 4.272

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Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-01       Impact factor: 11.205

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Authors:  Seong Hoon Ahn; Minkyu Kim; Stephen Buratowski
Journal:  Mol Cell       Date:  2004-01-16       Impact factor: 17.970

9.  Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes.

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10.  CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing.

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  78 in total

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Review 4.  Roles of Sumoylation in mRNA Processing and Metabolism.

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6.  AF4 and AF4N protein complexes: recruitment of P-TEFb kinase, their interactome and potential functions.

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Review 7.  Chromatin modification by the RNA Polymerase II elongation complex.

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Review 10.  Emerging roles for chromatin as a signal integration and storage platform.

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