Literature DB >> 22052791

Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography.

Cyril Ronco1, Eugénie Carletti, Jacques-Philippe Colletier, Martin Weik, Florian Nachon, Ludovic Jean, Pierre-Yves Renard.   

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Year:  2011        PMID： 22052791     DOI： 10.1002/cmdc.201100438

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


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  6 in total

1.  5-Methyl-N-(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5H-indolo[2,3-b]quinolin-11-amine: a highly potent human cholinesterase inhibitor.

Authors:  Li Wang; Ignacio Moraleda; Isabel Iriepa; Alejandro Romero; Francisco López-Muñoz; Mourad Chioua; Tsutomu Inokuchi; Manuela Bartolini; José Marco-Contelles
Journal:  Medchemcomm       Date:  2017-04-28       Impact factor: 3.597

2.  Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds.

Authors:  M Trapp; M Tehei; M Trovaslet; F Nachon; N Martinez; M M Koza; M Weik; P Masson; J Peters
Journal:  J R Soc Interface       Date:  2014-08-06       Impact factor: 4.118

3.  New amyloid beta-disaggregating agents: synthesis, pharmacological evaluation, crystal structure and molecular docking of N-(4-((7-chloroquinolin-4-yl)oxy)-3-ethoxybenzyl)amines.

Authors:  Tarana Umar; Shruti Shalini; Md Kausar Raza; Siddharth Gusain; Jitendra Kumar; Waqar Ahmed; Manisha Tiwari; Nasimul Hoda
Journal:  Medchemcomm       Date:  2018-08-20       Impact factor: 3.597

4.  Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study.

Authors:  Terrone L Rosenberry; Xavier Brazzolotto; Ian R Macdonald; Marielle Wandhammer; Marie Trovaslet-Leroy; Sultan Darvesh; Florian Nachon
Journal:  Molecules       Date:  2017-11-29       Impact factor: 4.411

5.  Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis.

Authors:  Carles Galdeano; Nicolas Coquelle; Monika Cieslikiewicz-Bouet; Manuela Bartolini; Belén Pérez; M Victòria Clos; Israel Silman; Ludovic Jean; Jacques-Philippe Colletier; Pierre-Yves Renard; Diego Muñoz-Torrero
Journal:  Molecules       Date:  2018-03-11       Impact factor: 4.411

6.  Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime.

Authors:  André-Guilhem Calas; Anne-Sophie Hanak; Nina Jaffré; Aurélie Nervo; José Dias; Catherine Rousseau; Charlotte Courageux; Xavier Brazzolotto; Pascal Villa; Adeline Obrecht; Jean-François Goossens; Christophe Landry; Johan Hachani; Fabien Gosselet; Marie-Pierre Dehouck; Jagadeesh Yerri; Maria Kliachyna; Rachid Baati; Florian Nachon
Journal:  Biomolecules       Date:  2020-06-04
  6 in total

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