BACKGROUND AND PURPOSE: Poststroke hyperglycemia and diabetes mellitus are associated with lower thrombolytic efficacy and an increased risk of postischemic cerebral hemorrhage. We aimed to develop a rodent model of thrombolysis in diabetic stroke that mimics the clinical situation. Method- Male 6-week Type I diabetic rats (14 weeks old) were subjected to embolic focal stroke and treated with tissue-type plasminogen activator at 1.5 hours. Reperfusion and 24-hour neurological outcomes were measured and compared with nondiabetic control rats. RESULTS: Diabetic rats exhibited resistance to thrombolytic reperfusion, larger infarction volumes, and increased intracerebral hemorrhage. CONCLUSIONS: This animal model would be relevant to future studies investigating pathophysiological mechanisms and in developing new therapeutic approaches to enhance the efficacy of tissue-type plasminogen activator thrombolysis in stroke patients with diabetes or poststroke hyperglycemia.
BACKGROUND AND PURPOSE:Poststroke hyperglycemia and diabetes mellitus are associated with lower thrombolytic efficacy and an increased risk of postischemic cerebral hemorrhage. We aimed to develop a rodent model of thrombolysis in diabetic stroke that mimics the clinical situation. Method- Male 6-week Type I diabeticrats (14 weeks old) were subjected to embolic focal stroke and treated with tissue-type plasminogen activator at 1.5 hours. Reperfusion and 24-hour neurological outcomes were measured and compared with nondiabetic control rats. RESULTS:Diabeticrats exhibited resistance to thrombolytic reperfusion, larger infarction volumes, and increased intracerebral hemorrhage. CONCLUSIONS: This animal model would be relevant to future studies investigating pathophysiological mechanisms and in developing new therapeutic approaches to enhance the efficacy of tissue-type plasminogen activator thrombolysis in strokepatients with diabetes or poststroke hyperglycemia.
Authors: A Riad; D Westermann; S Van Linthout; Z Mohr; S Uyulmaz; P M Becher; H Rütten; P Wohlfart; H Peters; H-P Schultheiss; C Tschöpe Journal: Diabetologia Date: 2008-09-30 Impact factor: 10.122
Authors: Xiaoying Wang; Kiyoshi Tsuji; Sun-Ryung Lee; MingMing Ning; Karen L Furie; Alastair M Buchan; Eng H Lo Journal: Stroke Date: 2004-09-30 Impact factor: 7.914
Authors: Li Zhang; Zheng Gang Zhang; Ruilan Zhang; Daniel Morris; Mei Lu; Barry S Coller; Michael Chopp Journal: Circulation Date: 2003-05-19 Impact factor: 29.690