Literature DB >> 22051138

A non-healing corneal ulcer as the presenting feature of type 1 diabetes mellitus: a case report.

Alexander S Ioannidis1, Sofia L Zagora, Alfred W Wechsler.   

Abstract

INTRODUCTION: Diabetic keratopathy is a rare complication of diabetes mellitus. This case illustrates the importance of checking blood sugar levels of patients with non-healing corneal ulcers to rule out the possibility of undiagnosed diabetes mellitus. CASE
PRESENTATION: We report the unusual case of a 24-year-old southeast Asian woman who presented with a sterile corneal ulcer to our hospital and later was found to be diabetic after a prolonged hospital stay. Despite all efforts, the corneal ulcer had failed to heal until treatment for previously undiagnosed diabetes was started. The sterile corneal ulcer began to heal once blood sugar levels began to normalize.
CONCLUSIONS: Diabetic keratopathy is a rare complication of diabetes mellitus and needs to be considered as a diagnosis in younger patients with non-healing sterile corneal ulcers. Blood sugar levels should be checked in these cases for undiagnosed diabetes mellitus.

Entities:  

Year:  2011        PMID: 22051138      PMCID: PMC3227724          DOI: 10.1186/1752-1947-5-539

Source DB:  PubMed          Journal:  J Med Case Rep        ISSN: 1752-1947


  9 in total

1.  Successful treatment of diabetic keratopathy with punctal occlusion.

Authors:  Akiko Sakamoto; Hiroshi Sasaki; Kazuko Kitagawa
Journal:  Acta Ophthalmol Scand       Date:  2004-02

Review 2.  Managing diabetic retinopathy.

Authors:  Zoe Ockrim; David Yorston
Journal:  BMJ       Date:  2010-10-25

3.  Prevention of diabetic keratopathy.

Authors:  Y Kaji
Journal:  Br J Ophthalmol       Date:  2005-03       Impact factor: 4.638

4.  Neurotrophic keratopathy and diabetes mellitus.

Authors:  A Lockwood; M Hope-Ross; P Chell
Journal:  Eye (Lond)       Date:  2005-10-07       Impact factor: 3.775

5.  Localization of aldose reductase in the human eye.

Authors:  Y Akagi; Y Yajima; P F Kador; T Kuwabara; J H Kinoshita
Journal:  Diabetes       Date:  1984-06       Impact factor: 9.461

6.  Decreased penetration of anchoring fibrils into the diabetic stroma. A morphometric analysis.

Authors:  D T Azar; S J Spurr-Michaud; A S Tisdale; I K Gipson
Journal:  Arch Ophthalmol       Date:  1989-10

7.  Naltrexone and insulin are independently effective but not additive in accelerating corneal epithelial healing in type I diabetic rats.

Authors:  Matthew S Klocek; Joseph W Sassani; Patricia J McLaughlin; Ian S Zagon
Journal:  Exp Eye Res       Date:  2009-07-01       Impact factor: 3.467

8.  Naltrexone, an opioid antagonist, facilitates reepithelialization of the cornea in diabetic rat.

Authors:  Ian S Zagon; Joe B Jenkins; Joseph W Sassani; James D Wylie; Torre B Ruth; Jamie L Fry; C Max Lang; Patricia J McLaughlin
Journal:  Diabetes       Date:  2002-10       Impact factor: 9.461

Review 9.  Aldose reductase in diabetic complications of the eye.

Authors:  J H Kinoshita; S Fukushi; P Kador; L O Merola
Journal:  Metabolism       Date:  1979-04       Impact factor: 8.694

  9 in total
  2 in total

1.  Corneal ulcer as the presenting feature of type 2 diabetes mellitus.

Authors:  Muhammad Kutubi; Alaric Smith
Journal:  BMJ Case Rep       Date:  2018-10-12

2.  Refractory Scedosporium apiospermum Keratitis Successfully Treated with Combination of Amphotericin B and Voriconazole.

Authors:  Mohd-Tahir Fadzillah; Siti-Raihan Ishak; Mohtar Ibrahim
Journal:  Case Rep Ophthalmol Med       Date:  2013-02-20
  2 in total

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