Glycosylation studies on conformationally restricted 3,5-O-(di-tert-butylsilylene)-D-galactofuranosyl trichloroacetimidate donors for 1,2-cis α-D-galactofuranosylation.

Conformationally restricted 3,5-O-di-tert-butylsilylene-D-galactofuranosyl trichloroacetimidate donors were synthesized from allyl α-D-galactofuranoside for the construction of 1,2-cis α-D-galactofuranosyl linkages. Glycosylation reactions were performed with several acceptors, including D-galactono-1,4-lactone, D-rhamnopyranosyl, and D-mannopyranosyl derivatives. The influence of the temperature and the reaction solvents was evaluated, as well as the 6-O-substitution pattern of the donor. The higher α-selectivities were obtained at -78 °C in diethyl ether as solvent. 6-O-Acetyl substitution on constrained donor increased the α-selectivity compared to the 6-O-benzyl substitution. Almost no selectivities were observed in the non-participating solvent CH(2)Cl(2). In contrast, ethereal solvents enhanced the α-selectivity suggesting a participating effect in the reaction intermediate.