Takeru Shimizu1, Shinichi Inomata, Makoto Tanaka. 1. Department of Anesthesiology and Critical Care Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan. takerushimizu@yahoo.co.jp
Abstract
STUDY OBJECTIVE: To compare the clinical efficacy of a rapid injection of propofol in regard to pain and ability to facilitate Laryngeal Mask Airway (LMA) insertion. DESIGN: Randomized, single-blinded, placebo-controlled study. SETTING:University hospital. PATIENTS: 120 ASA physical status 1 and 2 patients undergoing elective orthopedic surgeries. INTERVENTIONS: Patients were randomly allocated to one of 4 groups. Group A patients were pretreated with normal saline followed by propofol 2.0 mg/kg at 3.3 mg/sec. Group B patients were pretreated with lidocaine 0.5 mg/kg followed by propofol 2.0 mg/kg at 3.3 mg/sec. In Group C, patients were pretreated with lidocaine 1.0 mg/kg followed by propofol 2.0 mg/kg at 3.3 mg/sec. In Group D, patients were pretreated with normal saline followed by propofol 2.0 mg/kg at 50 mg/sec. MEASUREMENTS: Pain on injection was measured using a 4-point scale. Scale and success rate of smooth LMA insertion also were recorded. MAIN RESULTS: Rapid injection was less painful than after pretreatment with lidocaine 0.5 mg/kg, but was similar to slow injection after pretreatment with lidocaine 1.0 mg/kg. Rapid injection facilitated LMA insertion, unlike slow injection with lidocaine 0.5 mg/kg pretreatment, and was similarly successful to slow injection after pretreatment with lidocaine 1.0 mg/kg. CONCLUSIONS: The rapid administration of propofol reduces pain and facilitates LMA insertion versus slow administration of propofol. Copyright Â
RCT Entities:
STUDY OBJECTIVE: To compare the clinical efficacy of a rapid injection of propofol in regard to pain and ability to facilitate Laryngeal Mask Airway (LMA) insertion. DESIGN: Randomized, single-blinded, placebo-controlled study. SETTING: University hospital. PATIENTS: 120 ASA physical status 1 and 2 patients undergoing elective orthopedic surgeries. INTERVENTIONS:Patients were randomly allocated to one of 4 groups. Group A patients were pretreated with normal saline followed by propofol 2.0 mg/kg at 3.3 mg/sec. Group B patients were pretreated with lidocaine 0.5 mg/kg followed by propofol 2.0 mg/kg at 3.3 mg/sec. In Group C, patients were pretreated with lidocaine 1.0 mg/kg followed by propofol 2.0 mg/kg at 3.3 mg/sec. In Group D, patients were pretreated with normal saline followed by propofol 2.0 mg/kg at 50 mg/sec. MEASUREMENTS: Pain on injection was measured using a 4-point scale. Scale and success rate of smooth LMA insertion also were recorded. MAIN RESULTS: Rapid injection was less painful than after pretreatment with lidocaine 0.5 mg/kg, but was similar to slow injection after pretreatment with lidocaine 1.0 mg/kg. Rapid injection facilitated LMA insertion, unlike slow injection with lidocaine 0.5 mg/kg pretreatment, and was similarly successful to slow injection after pretreatment with lidocaine 1.0 mg/kg. CONCLUSIONS: The rapid administration of propofol reduces pain and facilitates LMA insertion versus slow administration of propofol. Copyright Â