Literature DB >> 22050749

Recent advance in aminopeptidase N (APN/CD13) inhibitor research.

X Zhang1, H Fang, J Zhang, Y Yuan, W Xu.   

Abstract

APN is an important zinc dependent metallo-exopeptidase, which can degrade the extracellular matrix, and plays an important role in tumor invasion, metastasis and angiogenesis. it has been considered as a suitable target for anti-cancer drug design. Recently, research of structure-based APN inhibitors is becoming an interesting field, and many APN inhibitors have been reported. Here we review a series of APN inhibitors and the recent progress in this field.

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Year:  2011        PMID： 22050749     DOI： 10.2174/092986711797535155

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  9 in total

1.  Discovery of Novel Tetrahydro-β-carboline Containing Aminopeptidase N Inhibitors as Cancer Chemosensitizers.

Authors:  Xiaoyan Xing; Fahui Li; Yajie Hu; Lin Zhang; Qian Hui; Hongyu Qin; Qixiao Jiang; Wenyan Jiang; Chunyan Fang; Lei Zhang
Journal:  Front Oncol       Date:  2022-05-23       Impact factor: 5.738

2.  Exploration of structural and physicochemical requirements and search of virtual hits for aminopeptidase N inhibitors.

Authors:  Amit K Halder; Achintya Saha; Tarun Jha
Journal:  Mol Divers       Date:  2013-01-23       Impact factor: 2.943

3.  APN-mediated phosphorylation of BCKDK promotes hepatocellular carcinoma metastasis and proliferation via the ERK signaling pathway.

Authors:  Mengying Zhai; Zixia Yang; Chenrui Zhang; Jinping Li; Jing Jia; Lingyi Zhou; Rong Lu; Zhi Yao; Zheng Fu
Journal:  Cell Death Dis       Date:  2020-05-26       Impact factor: 8.469

4.  Production of porcine aminopeptidase N (pAPN) site-specific edited pigs.

Authors:  Jianwen Chen; Kaiyuan Pan; Zhen Chen; Yunsheng Li; Biao Ding; Chunyang Han; Zubing Cao; Wenbin Bao; Yunhai Zhang
Journal:  Anim Sci J       Date:  2019-01-08       Impact factor: 1.749

Review 5.  The enzymes in COVID-19: A review.

Authors:  Maria Helena Menezes Estevam Alves; Layla Carvalho Mahnke; Tifany Cerqueira Macedo; Thais Ketinly Dos Santos Silva; Luiz Bezerra Carvalho Junior
Journal:  Biochimie       Date:  2022-01-26       Impact factor: 4.372

Review 6.  Validating Cell Surface Proteases as Drug Targets for Cancer Therapy: What Do We Know, and Where Do We Go?

Authors:  Emile Verhulst; Delphine Garnier; Ingrid De Meester; Brigitte Bauvois
Journal:  Cancers (Basel)       Date:  2022-01-26       Impact factor: 6.639

7.  CD13 and ROR2 Permit Isolation of Highly Enriched Cardiac Mesoderm from Differentiating Human Embryonic Stem Cells.

Authors:  Rhys J P Skelton; Bevin Brady; Suhail Khoja; Debashis Sahoo; James Engel; Deevina Arasaratnam; Kholoud K Saleh; Oscar J Abilez; Peng Zhao; Edouard G Stanley; Andrew G Elefanty; Murray Kwon; David A Elliott; Reza Ardehali
Journal:  Stem Cell Reports       Date:  2016-01-12       Impact factor: 7.765

8.  In Vivo Imaging of Hypoxia and Neoangiogenesis in Experimental Syngeneic Hepatocellular Carcinoma Tumor Model Using Positron Emission Tomography.

Authors:  Adrienn Kis; Judit P Szabó; Noémi Dénes; Adrienn Vágner; Gábor Nagy; Ildikó Garai; Anikó Fekete; Dezső Szikra; István Hajdu; Orsolya Matolay; Gábor Méhes; Gábor Mező; István Kertész; György Trencsényi
Journal:  Biomed Res Int       Date:  2020-08-07       Impact factor: 3.411

Review 9.  CD13: A Key Player in Multidrug Resistance in Cancer Chemotherapy.

Authors:  Qie Guo; Xiao Li; Meng-Na Cui; Jia-Lin Sun; Hong-Yan Ji; Bei-Bei Ni; Mei-Xing Yan
Journal:  Oncol Res       Date:  2020-06-12       Impact factor: 5.574
  9 in total

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