CONTEXT: The determinants of serum anti-Müllerian hormone (AMH) levels in adult men remain unclear. OBJECTIVE: The objective of the study was to investigate the genetic and environmental components in determining postpubertal AMH levels in healthy men. DESIGN AND PARTICIPANTS: Serum AMH levels, body mass index (BMI), and fat mass (dual energy x-ray absorptiometry) were measured in 64 healthy male (23 monozygotic and 41 dizygotic) twin pairs. RESULTS: Postpubertal AMH levels were highly genetically determined (broad sense heritability 0.92, 95% confidence interval 0.83-0.96). AMH correlated negatively with BMI (r = -0.26, P = 0.030) and fat mass (r = -0.23, P = 0.048). As AMH, BMI had a high heritability (0.68, 95% confidence interval 0.39-0.83), but no genetic correlation was observed between them. CONCLUSIONS: AMH levels in men after puberty are under a strong genetic influence. Twin modeling suggests that AMH and BMI are influenced by different sets of genes.
CONTEXT: The determinants of serum anti-Müllerian hormone (AMH) levels in adult men remain unclear. OBJECTIVE: The objective of the study was to investigate the genetic and environmental components in determining postpubertal AMH levels in healthy men. DESIGN AND PARTICIPANTS: Serum AMH levels, body mass index (BMI), and fat mass (dual energy x-ray absorptiometry) were measured in 64 healthy male (23 monozygotic and 41 dizygotic) twin pairs. RESULTS: Postpubertal AMH levels were highly genetically determined (broad sense heritability 0.92, 95% confidence interval 0.83-0.96). AMH correlated negatively with BMI (r = -0.26, P = 0.030) and fat mass (r = -0.23, P = 0.048). As AMH, BMI had a high heritability (0.68, 95% confidence interval 0.39-0.83), but no genetic correlation was observed between them. CONCLUSIONS:AMH levels in men after puberty are under a strong genetic influence. Twin modeling suggests that AMH and BMI are influenced by different sets of genes.
Authors: Martha M Sklavos; Cindy Ke Zhou; Ligia A Pinto; Michael B Cook Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-08-26 Impact factor: 4.254
Authors: Mara Y Roth; Kat Lin; Katrine Bay; John K Amory; Bradley D Anawalt; Alvin M Matsumoto; Brett T Marck; William J Bremner; Stephanie T Page Journal: Fertil Steril Date: 2012-10-03 Impact factor: 7.329
Authors: Jorunn M Andersen; Hilde Herning; Elin L Aschim; Jøran Hjelmesæth; Tom Mala; Hans Ivar Hanevik; Mona Bungum; Trine B Haugen; Oliwia Witczak Journal: PLoS One Date: 2015-06-12 Impact factor: 3.240