Literature DB >> 22049031

Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006.

Jenny J Zhang1, Tharanga N Senaratne, Rachel Daniels, Clarissa Valim, Michael Alifrangis, Priyanie Amerasinghe, Flemming Konradsen, Rupika Rajakaruna, Dyann F Wirth, Nadira D Karunaweera.   

Abstract

Widespread antimalarial resistance has been a barrier to malaria elimination efforts in Sri Lanka. Analysis of genetic markers in historic parasites may uncover trends in the spread of resistance. We examined the frequency of Plasmodium falciparum chloroquine transporter (pfcrt; codons 72-76) haplotypes in Sri Lanka in 1996-1998 and 2004-2006 using a high-resolution melting assay. Among 59 samples from 1996 to 1998, we detected the SVMNT (86%), CVMNK (10%), and CVIET (2%) haplotypes, with a positive trend in SVMNT and a negative trend in CVMNK frequency (P = 0.004) over time. Among 24 samples from 2004 to 2006, we observed only the SVMNT haplotype. This finding indicates selection for the SVMNT haplotype over time and its possible fixation in the population.

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Year:  2011        PMID： 22049031      PMCID： PMC3205623          DOI： 10.4269/ajtmh.2011.11-0167

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  12 in total

1.  Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.

Authors:  D A Fidock; T Nomura; A K Talley; R A Cooper; S M Dzekunov; M T Ferdig; L M Ursos; A B Sidhu; B Naudé; K W Deitsch; X Z Su; J C Wootton; P D Roepe; T E Wellems
Journal:  Mol Cell       Date:  2000-10       Impact factor: 17.970

2.  Molecular markers of chloroquine resistance in Plasmodium falciparum in Sri Lanka: frequency before revision of the antimalarial drug policy.

Authors:  H C Hapuarachchi; S Abeysundara; M Y D Dayanath; A Manamperi; W Abeyewickreme; N R de Silva
Journal:  Ann Trop Med Parasitol       Date:  2009-06

Review 3.  Spread and evolution of Plasmodium falciparum drug resistance.

Authors:  Toshihiro Mita; Kazuyuki Tanabe; Kiyoshi Kita
Journal:  Parasitol Int       Date:  2009-04-23       Impact factor: 2.230

4.  Evidence of selective sweeps in genes conferring resistance to chloroquine and pyrimethamine in Plasmodium falciparum isolates in India.

Authors:  Tonya Mixson-Hayden; Vidhan Jain; Andrea M McCollum; Amanda Poe; Avinash C Nagpal; Aditya P Dash; Jonathan K Stiles; Venkatachalam Udhayakumar; Neeru Singh
Journal:  Antimicrob Agents Chemother       Date:  2009-12-28       Impact factor: 5.191

5.  Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine.

Authors:  Juliana Martha Sá; Olivia Twu; Karen Hayton; Sahily Reyes; Michael P Fay; Pascal Ringwald; Thomas E Wellems
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-02       Impact factor: 11.205

6.  Sulphadoxine-pyrimethamine and chloroquine resistant Plasmodium falciparum infection in Sri Lanka.

Authors:  S M Handunnetti; S Jayasinghe; P P Pathirana; R Fernando; M H Sheriff; K N Mendis
Journal:  Ceylon Med J       Date:  1994-03

7.  Chloroquine resistant Plasmodium falciparum in Sri Lanka.

Authors:  R Ratnapala; K Subramaniam; M G Yapabandara; W P Fernando
Journal:  Ceylon Med J       Date:  1984-09

8.  A molecular marker for chloroquine-resistant falciparum malaria.

Authors:  A Djimdé; O K Doumbo; J F Cortese; K Kayentao; S Doumbo; Y Diourté; D Coulibaly; A Dicko; X Z Su; T Nomura; D A Fidock; T E Wellems; C V Plowe
Journal:  N Engl J Med       Date:  2001-01-25       Impact factor: 91.245

9.  The global distribution of clinical episodes of Plasmodium falciparum malaria.

Authors:  Robert W Snow; Carlos A Guerra; Abdisalan M Noor; Hla Y Myint; Simon I Hay
Journal:  Nature       Date:  2005-03-10       Impact factor: 49.962

10.  Genetic structure of Plasmodium falciparum and elimination of malaria, Comoros archipelago.

Authors:  Stanislas Rebaudet; Hervé Bogreau; Rahamatou Silaï; Jean François Lepere; Lionel Bertaux; Bruno Pradines; Jean Delmont; Philippe Gautret; Philippe Parola; Christophe Rogier
Journal:  Emerg Infect Dis       Date:  2010-11       Impact factor: 6.883
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  3 in total

1.  Microsatellite analysis of chloroquine resistance associated alleles and neutral loci reveal genetic structure of Indian Plasmodium falciparum.

Authors:  Prashant K Mallick; Patrick L Sutton; Ruchi Singh; Om P Singh; Aditya P Dash; Ashok K Singh; Jane M Carlton; Virendra K Bhasin
Journal:  Infect Genet Evol       Date:  2013-07-17       Impact factor: 3.342

Review 2.  Genetics of chloroquine-resistant malaria: a haplotypic view.

Authors:  Gauri Awasthi; Aparup Das
Journal:  Mem Inst Oswaldo Cruz       Date:  2013-12       Impact factor: 2.743

Review 3.  On the road to eliminate malaria in Sri Lanka: lessons from history, challenges, gaps in knowledge and research needs.

Authors:  Nadira D Karunaweera; Gawrie Nl Galappaththy; Dyann F Wirth
Journal:  Malar J       Date:  2014-02-18       Impact factor: 2.979
  3 in total

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