Literature DB >> 22048676

Origins of Western diseases.

Mj Quinn1.   

Abstract

Recent gynaecological studies show that childbirth, constipation, trauma and surgery cause injuries to autonomic nerves at different anatomical sites in the female pelvis resulting in endometriosis, adenomyosis and fibroids. Re-growth of abnormal nerves causes allodynic symptoms ('light touch causing pain or discomfort') some years later including vulvodynia, dyspareunia, dysmenorrhea, irritative bladder and bowel symptoms. Further consequences of autonomic denervation include tissue hypoplasia and hyperplasia, visceral dysfunction, susceptibility to infection, alcohol, tobacco and drugs, as well as pain with sensitization of the central nervous system. The 'autonomic denervation' view extrapolates these observations from the female pelvis to the varied anatomy of branches of the cardiac and coeliac plexi to provide primary mechanisms for many forms of Western disease. This account sets out the autonomic denervation view, identifies features of autonomic denervation in extrapelvic organs, and, contrasts it with prior accounts of chronic Western diseases including those of DP Burkitt, PRJ Burch and DP Barker.

Entities:  

Mesh:

Year:  2011        PMID: 22048676      PMCID: PMC3206721          DOI: 10.1258/jrsm.2011.110014

Source DB:  PubMed          Journal:  J R Soc Med        ISSN: 0141-0768            Impact factor:   5.344


  33 in total

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Authors:  Seeromanie Harding
Journal:  Int J Epidemiol       Date:  2004-04       Impact factor: 7.196

2.  The prevalence of hypertension in seven populations of west African origin.

Authors:  R Cooper; C Rotimi; S Ataman; D McGee; B Osotimehin; S Kadiri; W Muna; S Kingue; H Fraser; T Forrester; F Bennett; R Wilks
Journal:  Am J Public Health       Date:  1997-02       Impact factor: 9.308

3.  Constipation in very-low-birth-weight children at 10 to 14 years of age.

Authors:  C Cunningham; H G Taylor; N M Minich; M Hack
Journal:  J Pediatr Gastroenterol Nutr       Date:  2001-07       Impact factor: 2.839

4.  Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study.

Authors:  C J Murray; A D Lopez
Journal:  Lancet       Date:  1997-05-17       Impact factor: 79.321

5.  Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency.

Authors:  C L H Chan; P Facer; J B Davis; G D Smith; J Egerton; C Bountra; N S Williams; P Anand
Journal:  Lancet       Date:  2003-02-01       Impact factor: 79.321

6.  Cancers, infections, and endocrine diseases in women with endometriosis.

Authors:  Julie Anne L Gemmill; Pamela Stratton; Sean D Cleary; Mary Lou Ballweg; Ninet Sinaii
Journal:  Fertil Steril       Date:  2009-11-27       Impact factor: 7.329

7.  Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats.

Authors:  Qi Mei; Thomas O Mundinger; Ake Lernmark; Gerald J Taborsky
Journal:  Diabetes       Date:  2002-10       Impact factor: 9.461

8.  International parallels in leukaemia and diabetes epidemiology.

Authors:  R G Feltbower; P A McKinney; M F Greaves; R C Parslow; H J Bodansky
Journal:  Arch Dis Child       Date:  2004-01       Impact factor: 3.791

9.  Evidence for the ambiguity of the term constipation: the role of irritable bowel syndrome.

Authors:  C S Probert; P M Emmett; H A Cripps; K W Heaton
Journal:  Gut       Date:  1994-10       Impact factor: 23.059

10.  Straining at stool and laxative taking in an English population.

Authors:  K W Heaton; H A Cripps
Journal:  Dig Dis Sci       Date:  1993-06       Impact factor: 3.199

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