Literature DB >> 22048411

SHARPINing integrin inhibition.

Mark D Bass.   

Abstract

The activity state of integrins is crucial for cell adhesion, migration and differentiation, and is regulated predominantly by protein interactions of the integrin β cytoplasmic domain. SHARPIN is now shown to negatively regulate integrin activation by binding the α-integrin subunit and interfering with the association of the β cytodomain with activating proteins.

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Year:  2011        PMID： 22048411     DOI： 10.1038/ncb2368

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  15 in total

1.  The molecular basis of filamin binding to integrins and competition with talin.

Authors:  Tiila Kiema; Yatish Lad; Pengju Jiang; Camilla L Oxley; Massimiliano Baldassarre; Kate L Wegener; Iain D Campbell; Jari Ylänne; David A Calderwood
Journal:  Mol Cell       Date:  2006-02-03       Impact factor: 17.970

2.  Kindlin-2 controls bidirectional signaling of integrins.

Authors:  Eloi Montanez; Siegfried Ussar; Martina Schifferer; Michael Bösl; Roy Zent; Markus Moser; Reinhard Fässler
Journal:  Genes Dev       Date:  2008-05-15       Impact factor: 11.361

3.  Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.

Authors:  Nicholas J Anthis; Jacob R Haling; Camilla L Oxley; Massimiliano Memo; Kate L Wegener; Chinten J Lim; Mark H Ginsberg; Iain D Campbell
Journal:  J Biol Chem       Date:  2009-10-20       Impact factor: 5.157

Review 4.  New approaches to blockade of alpha4-integrins, proven therapeutic targets in chronic inflammation.

Authors:  Christiane Kummer; Mark H Ginsberg
Journal:  Biochem Pharmacol       Date:  2006-07-25       Impact factor: 5.858

5.  Newly identified tumor-associated role of human Sharpin.

Authors:  Jinyoung Jung; Jin Man Kim; Byoungwoo Park; Yeongmi Cheon; Bogman Lee; Seung Ho Choo; Sang Seok Koh; Soojin Lee
Journal:  Mol Cell Biochem       Date:  2010-02-24       Impact factor: 3.396

6.  An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration.

Authors:  Nicholas O Deakin; Mark D Bass; Stacey Warwood; Julia Schoelermann; Zohreh Mostafavi-Pour; David Knight; Christoph Ballestrem; Martin J Humphries
Journal:  J Cell Sci       Date:  2009-04-28       Impact factor: 5.285

7.  Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.

Authors:  R E Seymour; M G Hasham; G A Cox; L D Shultz; H Hogenesch; D C Roopenian; J P Sundberg
Journal:  Genes Immun       Date:  2007-05-31       Impact factor: 2.676

8.  Recreation of the terminal events in physiological integrin activation.

Authors:  Feng Ye; Guiqing Hu; Dianne Taylor; Boris Ratnikov; Andrey A Bobkov; Mark A McLean; Stephen G Sligar; Kenneth A Taylor; Mark H Ginsberg
Journal:  J Cell Biol       Date:  2010-01-04       Impact factor: 10.539

9.  Cellular growth and survival are mediated by beta 1 integrins in normal human breast epithelium but not in breast carcinoma.

Authors:  A R Howlett; N Bailey; C Damsky; O W Petersen; M J Bissell
Journal:  J Cell Sci       Date:  1995-05       Impact factor: 5.285

10.  Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinity.

Authors:  Angélique Millon-Frémillon; Daniel Bouvard; Alexei Grichine; Sandra Manet-Dupé; Marc R Block; Corinne Albiges-Rizo
Journal:  J Cell Biol       Date:  2008-01-28       Impact factor: 10.539
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  1 in total

1.  Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1.

Authors:  Juan Gao; Yun Bao; Shushu Ge; Peisen Sun; Jiaojiao Sun; Jianmin Liu; Feng Chen; Li Han; Zhongyuan Cao; Jun Qin; Gilbert C White; Zhen Xu; Yan-Qing Ma
Journal:  Cell Commun Signal       Date:  2019-08-20       Impact factor: 5.712
  1 in total

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