Literature DB >> 22047694

Antiprotozoal activity of proton-pump inhibitors.

Jaime Pérez-Villanueva1, Antonio Romo-Mancillas, Alicia Hernández-Campos, Lilián Yépez-Mulia, Francisco Hernández-Luis, Rafael Castillo.   

Abstract

Parasitic diseases are still a major health problem in developing countries. In our effort to find new antiparasitic agents, in this Letter we report the in vitro antiprotozoal activity of omeprazole, lansoprazole, rabeprazole and pantoprazole against Trichomonas vaginalis, Giardia intestinalis and Entamoeba histolytica. Molecular modeling studies were an important tool to highlight the potential antiprotozoal activity of these drugs. Experimental evaluations revealed a strong activity for all compounds tested. Rabeprazole and pantoprazole were the most active compounds, having IC(50) values in the nanomolar range, which were even better than metronidazole, the drug of choice for these parasites.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 22047694     DOI： 10.1016/j.bmcl.2011.10.028

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Rabeprazole inhibits several functions of Entamoeba histolytica related with its virulence.

Authors:  Yoalli Martínez-Pérez; Mario Nequiz-Avendaño; Itzhel García-Torres; Marco E Gudiño-Zayas; Gabriel López-Velázquez; Sergio Enríquez-Flores; Edith Mendoza; Emma Saavedra; Ruy Pérez-Tamayo; Gloria León-Avila; Alfonso Olivos-García
Journal:  Parasitol Res       Date:  2020-09-04       Impact factor: 2.289

2.  Giardial triosephosphate isomerase as possible target of the cytotoxic effect of omeprazole in Giardia lamblia.

Authors:  Horacio Reyes-Vivas; Ignacio de la Mora-de la Mora; Adriana Castillo-Villanueva; Lilian Yépez-Mulia; Gloria Hernández-Alcántara; Rosalia Figueroa-Salazar; Itzhel García-Torres; Saúl Gómez-Manzo; Sara T Méndez; América Vanoye-Carlo; Jaime Marcial-Quino; Angélica Torres-Arroyo; Jesús Oria-Hernández; Pedro Gutiérrez-Castrellón; Sergio Enríquez-Flores; Gabriel López-Velázquez
Journal:  Antimicrob Agents Chemother       Date:  2014-09-15       Impact factor: 5.191

3.  Assessment of the potential therapeutic effects of omeprazole in Schistosoma mansoni infected mice.

Authors:  Asmaa R Ellakany; Dina I Elgendy; Hanan A Alshenawy; Amira E Abdel Ghaffar
Journal:  Parasitol Res       Date:  2019-10-26       Impact factor: 2.289

4.  Novel giardicidal compounds bearing proton pump inhibitor scaffold proceeding through triosephosphate isomerase inactivation.

Authors:  B Hernández-Ochoa; G Navarrete-Vázquez; C Nava-Zuazo; A Castillo-Villanueva; S T Méndez; A Torres-Arroyo; S Gómez-Manzo; J Marcial-Quino; M Ponce-Macotela; Y Rufino-González; M Martínez-Gordillo; G Palencia-Hernández; N Esturau-Escofet; E Calderon-Jaimes; J Oria-Hernández; H Reyes-Vivas
Journal:  Sci Rep       Date:  2017-08-10       Impact factor: 4.379

5.  Proton pump inhibitors are associated with a reduced likelihood for sexually transmitted diseases in women in the emergency department.

Authors:  Johnathan Michael Sheele; Nathan Morris; Donald Byars; Frank Counselman
Journal:  Indian J Sex Transm Dis AIDS       Date:  2017 Jan-Jun

Review 6.  Treatment-refractory giardiasis: challenges and solutions.

Authors:  Marco Lalle; Kurt Hanevik
Journal:  Infect Drug Resist       Date:  2018-10-24       Impact factor: 4.003

7.  Enhanced Antigiardial Effect of Omeprazole Analog Benzimidazole Compounds.

Authors:  Beatriz Hernández-Ochoa; Saúl Gómez-Manzo; Adrián Sánchez-Carrillo; Jaime Marcial-Quino; Luz María Rocha-Ramírez; Araceli Santos-Segura; Edson Jiovany Ramírez-Nava; Roberto Arreguin-Espinosa; Miguel Cuevas-Cruz; Alfonso Méndez-Tenorio; Ernesto Calderón-Jaimes
Journal:  Molecules       Date:  2020-09-01       Impact factor: 4.411

8.  Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms.

Authors:  Giulliana T Almeida; Regina C G Lage; Leticia Anderson; Thiago M Venancio; Helder I Nakaya; Patrícia A Miyasato; Henrique K Rofatto; Adhemar Zerlotini; Eliana Nakano; Guilherme Oliveira; Sergio Verjovski-Almeida
Journal:  PLoS Negl Trop Dis       Date:  2015-09-24

9.  On the validity versus utility of activity landscapes: are all activity cliffs statistically significant?

Authors:  Rajarshi Guha; José L Medina-Franco
Journal:  J Cheminform       Date:  2014-04-02       Impact factor: 5.514

Review 10.  The Phylogeny and Biological Function of Gastric Juice-Microbiological Consequences of Removing Gastric Acid.

Authors:  Tom C Martinsen; Reidar Fossmark; Helge L Waldum
Journal:  Int J Mol Sci       Date:  2019-11-29       Impact factor: 5.923
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