Literature DB >> 22044656

Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells.

Darby G Brooke1, Elizabeth J Shelley, Caroline G Roberts, William A Denny, Robert L Sutherland, Alison J Butt.   

Abstract

A structure-activity study of several new synthetic analogues of the avocado-produced toxin persin has been conducted, with compounds being evaluated for their cytostatic and pro-apoptotic effects in human breast cancer cells. A 4-pyridinyl derivative demonstrated activity comparable to that of the natural product, suggesting future directions for exploration of structure-activity relationships.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 22044656     DOI： 10.1016/j.bmc.2011.10.006

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  7 in total

1.  Microtubule-stabilizing properties of the avocado-derived toxins (+)-(R)-persin and (+)-(R)-tetrahydropersin in cancer cells and activity of related synthetic analogs.

Authors:  Jessica J Field; Arun Kanakkanthara; Darby G Brooke; Saptarshi Sinha; Sushila D Pillai; William A Denny; Alison J Butt; John H Miller
Journal:  Invest New Drugs       Date:  2016-03-12       Impact factor: 3.850

2.  Nutritional and physico-chemical implications of avocado meal as a novel dietary fiber source in an extruded canine diet.

Authors:  Amanda N Dainton; Fei He; Tanner W Bingham; David Sarlah; Katelyn B Detweiler; Heather J Mangian; Maria Regina Cattai de Godoy
Journal:  J Anim Sci       Date:  2022-02-01       Impact factor: 3.159

3.  Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells.

Authors:  R A McCloy; E J Shelley; C G Roberts; E Boslem; T J Biden; R I Nicholson; J M Gee; R L Sutherland; E A Musgrove; A Burgess; A J Butt
Journal:  Br J Cancer       Date:  2013-10-31       Impact factor: 7.640

Review 4.  The Odyssey of Bioactive Compounds in Avocado (Persea americana) and Their Health Benefits.

Authors:  Deep Jyoti Bhuyan; Muhammad A Alsherbiny; Saumya Perera; Mitchell Low; Amrita Basu; Okram Abemsana Devi; Mridula Saikia Barooah; Chun Guang Li; Konstantinos Papoutsis
Journal:  Antioxidants (Basel)       Date:  2019-09-24

Review 5.  Beyond the Paclitaxel and Vinca Alkaloids: Next Generation of Plant-Derived Microtubule-Targeting Agents with Potential Anticancer Activity.

Authors:  Dangquan Zhang; Arun Kanakkanthara
Journal:  Cancers (Basel)       Date:  2020-06-29       Impact factor: 6.639

6.  Deep sequencing of the Mexican avocado transcriptome, an ancient angiosperm with a high content of fatty acids.

Authors:  Enrique Ibarra-Laclette; Alfonso Méndez-Bravo; Claudia Anahí Pérez-Torres; Victor A Albert; Keithanne Mockaitis; Aruna Kilaru; Rodolfo López-Gómez; Jacob Israel Cervantes-Luevano; Luis Herrera-Estrella
Journal:  BMC Genomics       Date:  2015-08-13       Impact factor: 3.969

7.  Avocado fruit maturation and ripening: dynamics of aliphatic acetogenins and lipidomic profiles from mesocarp, idioblasts and seed.

Authors:  Carlos Eduardo Rodríguez-López; Carmen Hernández-Brenes; Víctor Treviño; Rocío I Díaz de la Garza
Journal:  BMC Plant Biol       Date:  2017-09-29       Impact factor: 4.215
  7 in total

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