| Literature DB >> 22044048 |
Ying-Mei Li1, Xiang Li, Fang-Zhi Peng, Ze-Qian Li, Shou-Tao Wu, Zhong-Wen Sun, Hong-Bin Zhang, Zhi-Hui Shao.
Abstract
Biologically important and synthetically challenging spirocyclopentaneoxindoles with four contiguous stereocenters including one spiroquaternary stereocenter have been constructed in good yields (72-87%) with excellent diastereoselectivity (16:1→30:1 dr) and enantioselectivity (93→99% ee) by a combined Ru-catalyzed cross-metathesis/organocatalyzed asymmetric double-Michael addition sequence.Entities:
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Year: 2011 PMID： 22044048 DOI： 10.1021/ol202624f
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005