OBJECTIVES: This study examines the effects of total light deprivation on the developing lateral geniculate nucleus, the primary integration centre for visual information METHODS: Sprague-Dawley rats were reared for one month in a dark room from 7th postnatal day before eye opening. A group of rats was taken back into normal condition for 15 days, and then perfused. Coronal sections of LGN were prepared and stained with Cresyl Violet and Cytochrome Oxidase to investigate the number of neurons, volume and length, as well as neuronal activity level. RESULTS: The results showed that LD for one month causes progressive loss of neurons and decreases neuronal activity level in the LGN. CONCLUSION: It can be concluded that during early postnatal development of the rats' visual system, light deprivation causes structural and functional changes in LGN.
OBJECTIVES: This study examines the effects of total light deprivation on the developing lateral geniculate nucleus, the primary integration centre for visual information METHODS:Sprague-Dawley rats were reared for one month in a dark room from 7th postnatal day before eye opening. A group of rats was taken back into normal condition for 15 days, and then perfused. Coronal sections of LGN were prepared and stained with Cresyl Violet and Cytochrome Oxidase to investigate the number of neurons, volume and length, as well as neuronal activity level. RESULTS: The results showed that LD for one month causes progressive loss of neurons and decreases neuronal activity level in the LGN. CONCLUSION: It can be concluded that during early postnatal development of the rats' visual system, light deprivation causes structural and functional changes in LGN.
Authors: C Nucci; S Piccirilli; P Rodinò; R Nisticò; M Grandinetti; L Cerulli; M Leist; P Nicotera; G Bagetta Journal: Biochem Biophys Res Commun Date: 2000-11-19 Impact factor: 3.575
Authors: Katharine L Campi; Christine E Collins; William D Todd; Jon Kaas; Leah Krubitzer Journal: Brain Behav Evol Date: 2011-04-28 Impact factor: 1.808
Authors: Geoffrey K Aguirre; Omar H Butt; Ritobrato Datta; Alejandro J Roman; Alexander Sumaroka; Sharon B Schwartz; Artur V Cideciyan; Samuel G Jacobson Journal: Invest Ophthalmol Vis Sci Date: 2017-02-01 Impact factor: 4.799