Literature DB >> 22042895

Don't know, can't know: embracing deeper uncertainties when analysing risks.

David J Spiegelhalter1, Hauke Riesch.   

Abstract

Numerous types of uncertainty arise when using formal models in the analysis of risks. Uncertainty is best seen as a relation, allowing a clear separation of the object, source and 'owner' of the uncertainty, and we argue that all expressions of uncertainty are constructed from judgements based on possibly inadequate assumptions, and are therefore contingent. We consider a five-level structure for assessing and communicating uncertainties, distinguishing three within-model levels--event, parameter and model uncertainty--and two extra-model levels concerning acknowledged and unknown inadequacies in the modelling process, including possible disagreements about the framing of the problem. We consider the forms of expression of uncertainty within the five levels, providing numerous examples of the way in which inadequacies in understanding are handled, and examining criticisms of the attempts taken by the Intergovernmental Panel on Climate Change to separate the likelihood of events from the confidence in the science. Expressing our confidence in the adequacy of the modelling process requires an assessment of the quality of the underlying evidence, and we draw on a scale that is widely used within evidence-based medicine. We conclude that the contingent nature of risk-modelling needs to be explicitly acknowledged in advice given to policy-makers, and that unconditional expressions of uncertainty remain an aspiration.

Year:  2011        PMID: 22042895     DOI: 10.1098/rsta.2011.0163

Source DB:  PubMed          Journal:  Philos Trans A Math Phys Eng Sci        ISSN: 1364-503X            Impact factor:   4.226


  11 in total

1.  Estimation of Breast Cancer Overdiagnosis in a U.S. Breast Screening Cohort.

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Journal:  Ann Intern Med       Date:  2022-03-01       Impact factor: 51.598

Review 2.  Conceptual, methodological, and ethical problems in communicating uncertainty in clinical evidence.

Authors:  Paul K J Han
Journal:  Med Care Res Rev       Date:  2012-11-06       Impact factor: 3.929

3.  Use and cumulation of evidence from modelling studies to inform policy on food taxes and subsidies: biting off more than we can chew?

Authors:  Ian Shemilt; Theresa M Marteau; Richard D Smith; David Ogilvie
Journal:  BMC Public Health       Date:  2015-03-27       Impact factor: 3.295

4.  Communicating uncertainty in seasonal and interannual climate forecasts in Europe.

Authors:  Andrea L Taylor; Suraje Dessai; Wändi Bruine de Bruin
Journal:  Philos Trans A Math Phys Eng Sci       Date:  2015-11-28       Impact factor: 4.226

5.  Improving the use of crop models for risk assessment and climate change adaptation.

Authors:  Andrew J Challinor; Christoph Müller; Senthold Asseng; Chetan Deva; Kathryn Jane Nicklin; Daniel Wallach; Eline Vanuytrecht; Stephen Whitfield; Julian Ramirez-Villegas; Ann-Kristin Koehler
Journal:  Agric Syst       Date:  2018-01       Impact factor: 5.370

6.  The value of personalised risk information: a qualitative study of the perceptions of patients with prostate cancer.

Authors:  Paul K J Han; Norbert Hootsmans; Michael Neilson; Bethany Roy; Terence Kungel; Caitlin Gutheil; Michael Diefenbach; Moritz Hansen
Journal:  BMJ Open       Date:  2013-09-13       Impact factor: 2.692

Review 7.  Predictive systems ecology.

Authors:  Matthew R Evans; Mike Bithell; Stephen J Cornell; Sasha R X Dall; Sandra Díaz; Stephen Emmott; Bruno Ernande; Volker Grimm; David J Hodgson; Simon L Lewis; Georgina M Mace; Michael Morecroft; Aristides Moustakas; Eugene Murphy; Tim Newbold; K J Norris; Owen Petchey; Matthew Smith; Justin M J Travis; Tim G Benton
Journal:  Proc Biol Sci       Date:  2013-10-02       Impact factor: 5.349

Review 8.  Towards inclusive social appraisal: risk, participation and democracy in governance of synthetic biology.

Authors:  Andrew Stirling; K R Hayes; Jason Delborne
Journal:  BMC Proc       Date:  2018-07-19

9.  Assessing the aggregated probability of entry of a novel prion disease agent into the United Kingdom.

Authors:  Verity Horigan; Paul Gale; Amie Adkin; Timm Konold; Claire Cassar; John Spiropoulos; Louise Kelly
Journal:  Microb Risk Anal       Date:  2020-08-15

10.  Point: Uncertainty about estimating the risks of COVID-19 during pregnancy.

Authors:  Kristin Palmsten; Gabriela Vazquez-Benitez; Elyse O Kharbanda
Journal:  Paediatr Perinat Epidemiol       Date:  2021-07-13       Impact factor: 3.103

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