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Literature DB >> 2204242

Inactivation of viral antigens for vaccine preparation with particular reference to the application of binary ethylenimine.

Abstract

Viral antigens for human and veterinary vaccines are still inactivated with formaldehyde. This is not an ideal inactivant and the problems of formaldehyde inactivation of vaccines are discussed. Vaccines inactivated with aziridines are superior in safety and antigenicity. Aziridines inactivate viruses in a first-order reaction and the inactivation rate and endpoint can be determined. The preparation and application of the aziridine compound binary ethylenimine (BEI) and the necessary conditions for and controls of the inactivation process are described and discussed. A computer program has been written for assistance in the use of BEI for controlled inactivation of viral antigens.

Entities: Chemical Disease Species

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Year: 1990 PMID： 2204242 PMCID： PMC7173316 DOI： 10.1016/0264-410x(90)90083-x

Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641

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Authors: Donata Kalthoff; Susanne Röhrs; Dirk Höper; Bernd Hoffmann; Jessica Bogs; Jürgen Stech; Martin Beer
Journal: J Virol Date: 2013-10-09 Impact factor: 5.103

6. An inactivated vaccine from a field strain of bovine herpesvirus-1 (BoHV-1) has high antigenic mass and induces strong efficacy in a rabbit model.

Authors: Julian Ruiz-Sáenz; Jairo Jaime; Victor Vera
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7. Protective humoral immune response induced by an inactivated porcine reproductive and respiratory syndrome virus expressing the hypo-glycosylated glycoprotein 5.

Authors: Jung-Ah Lee; Byungjoon Kwon; Fernando A Osorio; Asit K Pattnaik; Nak-Hyung Lee; Sang-Won Lee; Seung-Yong Park; Chang-Seon Song; In-Soo Choi; Joong-Bok Lee
Journal: Vaccine Date: 2014-05-09 Impact factor: 3.641