| Literature DB >> 22041931 |
David J Moore1, Carolina Posada, Mili Parikh, Miguel Arce, Florin Vaida, Patricia K Riggs, Ben Gouaux, Ronald J Ellis, Scott L Letendre, Igor Grant, J Hampton Atkinson.
Abstract
The contribution of bipolar disorder (BD), a prevalent serious mental illness characterized by impulsivity and mood instability, to antiretroviral (ART) and psychiatric medication adherence among HIV-infected (HIV+) individuals is unknown. We examined medication adherence among 44 HIV+/BD+ persons as compared to 33 demographically- and medically-comparable HIV+/BD- persons. Classification of adherent (≥ 90%) or non-adherent (<90%) based on proportion of correctly taken doses over 30 days was determined using electronic medication monitoring devices. HIV+/BD+ persons were significantly less likely to be ART adherent (47.7%) as compared to HIV+/BD- (90.9%) persons. Within the HIV+/BD+ group, mean psychiatric medication adherence was significantly worse than ART medication adherence, although there was a significant correlation between ART and psychiatric adherence levels. Importantly, 30-day ART adherence was associated with plasma virologic response among HIV+/BD+ individuals. Given the high overlap of HIV and BD, and the observed medication adherence difficulties for these persons, specialized adherence improvement interventions are needed.Entities:
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Year: 2012 PMID： 22041931 PMCID： PMC3351543 DOI： 10.1007/s10461-011-0072-2
Source DB: PubMed Journal: AIDS Behav ISSN： 1090-7165