Literature DB >> 22041907

Continuous in situ generation and reaction of phosgene in a microflow system.

Shinichiro Fuse1, Nobutake Tanabe, Takashi Takahashi.   

Abstract

Continuous in situ generation of phosgene and its use in acid chloride formation in a microflow system were demonstrated. The acid chloride was subsequently coupled with an amine in high yield without severe epimerization.

Entities:  

Year:  2011        PMID： 22041907     DOI： 10.1039/c1cc15662d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  On-demand in situ generation of oxygen in a nanofluidic embedded planar microband electrochemical reactor.

Authors:  Wei Xu; Erick Foster; Chaoxiong Ma; Paul W Bohn
Journal:  Microfluid Nanofluidics       Date:  2015-09-09       Impact factor: 2.529

2.  A decade review of triphosgene and its applications in organic reactions.

Authors:  Moshood O Ganiu; Binod Nepal; Joshua P Van Houten; Rendy Kartika
Journal:  Tetrahedron       Date:  2020-09-06       Impact factor: 2.457

3.  Efficient amide bond formation through a rapid and strong activation of carboxylic acids in a microflow reactor.

Authors:  Shinichiro Fuse; Yuto Mifune; Takashi Takahashi
Journal:  Angew Chem Int Ed Engl       Date:  2013-12-02       Impact factor: 15.336

4.  Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation.

Authors:  Shinichiro Fuse; Yuto Mifune; Hiroyuki Nakamura; Hiroshi Tanaka
Journal:  Nat Commun       Date:  2016-11-28       Impact factor: 14.919

5.  Micro-flow synthesis and structural analysis of sterically crowded diimine ligands with five aryl rings.

Authors:  Shinichiro Fuse; Nobutake Tanabe; Akio Tannna; Yohei Konishi; Takashi Takahashi
Journal:  Beilstein J Org Chem       Date:  2013-11-01       Impact factor: 2.883

6.  The Concept of Chemical Generators: On-Site On-Demand Production of Hazardous Reagents in Continuous Flow.

Authors:  Doris Dallinger; Bernhard Gutmann; C Oliver Kappe
Journal:  Acc Chem Res       Date:  2020-06-16       Impact factor: 22.384
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.