| Literature DB >> 22041454 |
Jie Liu1, Liu Cao, Toren Finkel.
Abstract
Adult stem cells persist throughout the lifetime of the organism and may therefore require specific mechanisms to limit the effects of chronic oxidative stress. Recently, several instructive genetic mouse models have demonstrated the unique susceptibility of stem cells to perturbations in metabolic or redox homeostasis. These results have implications not only for stem cell biology but also suggest a mechanistic link between intracellular oxidants and the decline in regenerative function that occurs as a normal consequence of aging. Published by Elsevier Inc.Entities:
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Year: 2011 PMID: 22041454 PMCID: PMC3757472 DOI: 10.1016/j.freeradbiomed.2011.10.434
Source DB: PubMed Journal: Free Radic Biol Med ISSN: 0891-5849 Impact factor: 7.376