BACKGROUND: Osteoclast-associated receptor (OSCAR) is a member of the newly identified leukocyte receptor complex, and has recently been described as a key molecule in osteoclastogenesis. In this study, we measured the levels of soluble osteoclast-associated receptor (sOSCAR) in the serum of rheumatoid arthritis (RA) patients and healthy controls to examine whether sOSCAR may play a role in the process of inflammatory arthritis. METHODS: Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of sOSCAR in the serum of 40 healthy controls and 40 RA patients. RESULTS: The serum levels of sOSCAR were significantly lower in RA patients than in healthy controls, and were inversely associated with inflammatory activity. CONCLUSION: sOSCAR is decreased in patients with RA and reduced levels of the protein are associated with increased inflammatory response.
BACKGROUND:Osteoclast-associated receptor (OSCAR) is a member of the newly identified leukocyte receptor complex, and has recently been described as a key molecule in osteoclastogenesis. In this study, we measured the levels of soluble osteoclast-associated receptor (sOSCAR) in the serum of rheumatoid arthritis (RA) patients and healthy controls to examine whether sOSCAR may play a role in the process of inflammatory arthritis. METHODS: Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of sOSCAR in the serum of 40 healthy controls and 40 RApatients. RESULTS: The serum levels of sOSCAR were significantly lower in RApatients than in healthy controls, and were inversely associated with inflammatory activity. CONCLUSION: sOSCAR is decreased in patients with RA and reduced levels of the protein are associated with increased inflammatory response.
Authors: Anak A S S K Dharmapatni; Kent Algate; Roxanne Coleman; Michelle Lorimer; Melissa D Cantley; Malcolm D Smith; Mihir D Wechalekar; Tania N Crotti Journal: Inflammation Date: 2017-10 Impact factor: 4.092
Authors: Tania N Crotti; Anak A S S K Dharmapatni; Ekram Alias; Andrew C W Zannettino; Malcolm D Smith; David R Haynes Journal: Arthritis Res Ther Date: 2012-11-12 Impact factor: 5.156