BACKGROUND: The clinical benefits of intensive stroke rehabilitation vary individually. We used multimodal functional imaging to assess the relationship of clinical gain and imaging changes in patients with chronic stroke whose voluntary motor control improved after constraint-induced movement therapy (CIMT). METHODS: Eleven patients (37.6 ± 36.8 months from stroke) were studied by functional MRI (fMRI), transcranial magnetic stimulation (TMS), and behavioral assessment of hand motor control (Wolf Motor Function Test) before and after 2 weeks of CIMT. Individual and group-level changes in imaging and behavioral parameters were investigated. RESULTS: Increase in fMRI activation in the sensorimotor areas was greater amongst those subjects who had poor hand motor behavior before therapy and/or whose motor behavior improved notably because of therapy than amongst subjects with relatively good motor behavior already before therapy. The magnitude of CIMT-induced changes in task-related fMRI activation differed between lesioned and non-lesioned hemispheres, and the fMRI laterality index was different for paretic and non-paretic hand tasks. The corticospinal conduction time in TMS was significantly decreased after CIM therapy. CONCLUSIONS: Alterations in sensorimotor cortical activations (fMRI) and corticospinal conductivity (TMS) were observed after intensive rehabilitation in patients with chronic stroke. Activation and functional changes in fMRI and TMS correlated significantly with the degree of clinical improvement in hand motor behavior. The present data advance the understanding of the functional underpinnings of motor recovery, which may be obtained even years after the stroke.
BACKGROUND: The clinical benefits of intensive stroke rehabilitation vary individually. We used multimodal functional imaging to assess the relationship of clinical gain and imaging changes in patients with chronic stroke whose voluntary motor control improved after constraint-induced movement therapy (CIMT). METHODS: Eleven patients (37.6 ± 36.8 months from stroke) were studied by functional MRI (fMRI), transcranial magnetic stimulation (TMS), and behavioral assessment of hand motor control (Wolf Motor Function Test) before and after 2 weeks of CIMT. Individual and group-level changes in imaging and behavioral parameters were investigated. RESULTS: Increase in fMRI activation in the sensorimotor areas was greater amongst those subjects who had poor hand motor behavior before therapy and/or whose motor behavior improved notably because of therapy than amongst subjects with relatively good motor behavior already before therapy. The magnitude of CIMT-induced changes in task-related fMRI activation differed between lesioned and non-lesioned hemispheres, and the fMRI laterality index was different for paretic and non-paretic hand tasks. The corticospinal conduction time in TMS was significantly decreased after CIM therapy. CONCLUSIONS: Alterations in sensorimotor cortical activations (fMRI) and corticospinal conductivity (TMS) were observed after intensive rehabilitation in patients with chronic stroke. Activation and functional changes in fMRI and TMS correlated significantly with the degree of clinical improvement in hand motor behavior. The present data advance the understanding of the functional underpinnings of motor recovery, which may be obtained even years after the stroke.
Authors: David O Kamson; Csaba Juhász; Joseph Shin; Michael E Behen; William C Guy; Harry T Chugani; Jeong-Won Jeong Journal: Pediatr Neurol Date: 2013-12-18 Impact factor: 3.372
Authors: Kathleen M Friel; Hsing-Ching Kuo; Jason Fuller; Claudio L Ferre; Marina Brandão; Jason B Carmel; Yannick Bleyenheuft; Jaimie L Gowatsky; Arielle D Stanford; Stefan B Rowny; Bruce Luber; Bruce Bassi; David L K Murphy; Sarah H Lisanby; Andrew M Gordon Journal: Neurorehabil Neural Repair Date: 2016-02-11 Impact factor: 3.919
Authors: Brittany M Young; Zack Nigogosyan; Léo M Walton; Alexander Remsik; Jie Song; Veena A Nair; Mitchell E Tyler; Dorothy F Edwards; Kristin Caldera; Justin A Sattin; Justin C Williams; Vivek Prabhakaran Journal: Front Hum Neurosci Date: 2015-06-23 Impact factor: 3.169
Authors: Brittany M Young; Zack Nigogosyan; Léo M Walton; Jie Song; Veena A Nair; Scott W Grogan; Mitchell E Tyler; Dorothy F Edwards; Kristin Caldera; Justin A Sattin; Justin C Williams; Vivek Prabhakaran Journal: Front Neuroeng Date: 2014-07-15