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Literature DB >> 22039308

LED-Based Optical Device for Chronic In Vivo Cerebral Blood Volume Measurement.

Marshall P Cox¹, Hongtao Ma, Matthias E Bahlke, Jonathan H Beck, Theodore H Schwartz, Ioannis Kymissis.

Abstract

We demonstrate a reflectivity-based cerebral blood volume sensor comprised of surface-mount light-emitting diodes on a flexible substrate with integrated photodetectors in a form factor suitable for direct brain contact and chronic implantation. This reflectivity monitor is able to measure blood flow through the change of the surface reflectivity and, through this mechanism, detect the cerebral-blood-volume changes associated with epileptic seizures with a signal-to-noise (SNR) response of 42 dB. The device is tested in an in vivo model confirming its compatibility and sensitivity. The data taken demonstrate that placing the sensor into direct brain contact improves the SNR by more than four orders of magnitude over current noncontact technologies.

Entities: Chemical Disease Gene Mutation Species

Year: 2010 PMID： 22039308 PMCID： PMC3203522 DOI： 10.1109/TED.2009.2033652

Source DB: PubMed Journal: IEEE Trans Electron Devices ISSN： 0018-9383 Impact factor: 2.917

10 in total

1. Evaluation of coupling between optical intrinsic signals and neuronal activity in rat somatosensory cortex.

Authors: Sameer Sheth; Masahito Nemoto; Michael Guiou; Melissa Walker; Nader Pouratian; Arthur W Toga
Journal: Neuroimage Date: 2003-07 Impact factor: 6.556

Review 2. Optical imaging of intrinsic signals: recent developments in the methodology and its applications.

Authors: Angelica Zepeda; Clorinda Arias; Frank Sengpiel
Journal: J Neurosci Methods Date: 2004-06-15 Impact factor: 2.390

Review 3. National Institutes of Health Consensus Development Conference Statement: Surgery for Epilepsy, March 19-21, 1990.

Authors:
Journal: Epilepsia Date: 1990 Nov-Dec Impact factor: 5.864

Review 4. Management of seizures and epilepsy.

Authors: W J Marks; P A Garcia
Journal: Am Fam Physician Date: 1998-04-01 Impact factor: 3.292

5. Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping.

Authors: D Malonek; A Grinvald
Journal: Science Date: 1996-04-26 Impact factor: 47.728

6. The importance of latency in the focality of perfusion and oxygenation changes associated with triggered afterdischarges in human cortex.

Authors: Hongtao Ma; Andrew Geneslaw; Mingrui Zhao; Minah Suh; Challon Perry; Theodore H Schwartz
Journal: J Cereb Blood Flow Metab Date: 2009-03-18 Impact factor: 6.200

7. Blood volume and hemoglobin oxygenation response following electrical stimulation of human cortex.

Authors: Minah Suh; Sonya Bahar; Ashesh D Mehta; Theodore H Schwartz
Journal: Neuroimage Date: 2006-02-15 Impact factor: 6.556

8. Intrinsic optical signal imaging of neocortical seizures: the 'epileptic dip'.

Authors: Sonya Bahar; Minah Suh; Mingrui Zhao; Theodore H Schwartz
Journal: Neuroreport Date: 2006-04-03 Impact factor: 1.837

9. Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography.

Authors: Qizhi Zhang; Zhao Liu; Paul R Carney; Zhen Yuan; Huanxin Chen; Steven N Roper; Huabei Jiang
Journal: Phys Med Biol Date: 2008-03-11 Impact factor: 3.609

10. Neurovascular coupling and epilepsy: hemodynamic markers for localizing and predicting seizure onset.

Authors: Theodore H Schwartz
Journal: Epilepsy Curr Date: 2007 Jul-Aug Impact factor: 7.500

10 in total

5 in total

LED-Based Optical Device for Chronic In Vivo Cerebral Blood Volume Measurement.

1. Evaluation of coupling between optical intrinsic signals and neuronal activity in rat somatosensory cortex.

Review 2. Optical imaging of intrinsic signals: recent developments in the methodology and its applications.

Review 3. National Institutes of Health Consensus Development Conference Statement: Surgery for Epilepsy, March 19-21, 1990.

Review 4. Management of seizures and epilepsy.

5. Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping.

6. The importance of latency in the focality of perfusion and oxygenation changes associated with triggered afterdischarges in human cortex.

7. Blood volume and hemoglobin oxygenation response following electrical stimulation of human cortex.

8. Intrinsic optical signal imaging of neocortical seizures: the 'epileptic dip'.

9. Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography.

10. Neurovascular coupling and epilepsy: hemodynamic markers for localizing and predicting seizure onset.

Review 1. Optogenetic tools for modulating and probing the epileptic network.

2. Tissue hypoxia correlates with intensity of interictal spikes.

Review 3. Imaging preictal hemodynamic changes in neocortical epilepsy.

Review 4. Microbial Proteins as Novel Industrial Biotechnology Hosts to Treat Epilepsy.

5. Multimodal Detection for Cryptogenic Epileptic Seizures Based on Combined Micro Sensors.