Literature DB >> 22038299

A multi-component domino reaction for the direct access to polyfunctionalized indoles via intermolecular allylic esterification and indolation.

Bo Jiang1, Mian-Shuai Yi, Feng Shi, Shu-Jiang Tu, Suresh Pindi, Patrick McDowell, Guigen Li.   

Abstract

A novel multi-component reaction for the synthesis of polyfunctionalized indoles and bis-indoles has been established. The reaction pathways were controlled by varying enamines with different substitution patterns to give polyfunctionalized indoles and bis-indoles selectively. The reaction proceeds at a fast speed within 15-30 min with water as the major byproduct, which makes work-up convenient. This journal is © The Royal Society of Chemistry 2012

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Year:  2011        PMID： 22038299      PMCID： PMC3691686          DOI： 10.1039/c1cc15913e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  35 in total

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  11 in total

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6.  Allylic amination and N-arylation-based domino reactions providing rapid three-component strategies to fused pyrroles with different substituted patterns.

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7.  Divergent synthesis of dual 1,4-dihydropyridines with different substituted patterns from enaminones and aldehydes through domino reactions.

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