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Literature DB >> 2203828

Restricted expression of the erythroid/brain glucose transporter isoform to perivenous hepatocytes in rats. Modulation by glucose.

M Tal¹, D L Schneider, B Thorens, H F Lodish.

Abstract

The "erythroid/brain" glucose transporter (GT) isoform is expressed only in a subset of hepatocytes, those forming the first row around the terminal hepatic venules, while the "liver" GT is expressed in all hepatocytes. After 3 d of starvation, a three- to fourfold elevation of expression of the erythroid/brain GT mRNA and protein is detected in the liver as a whole; this correlates with the expression of this GT in more hepatocytes, those forming the first three to four rows around the hepatic venules. Starvation-dependent expression of the erythroid/brain GT on the plasma membrane of these additional hepatocytes is lost within 3 h of glucose refeeding; however, by immunoblotting we show that the protein is still present. Its loss from the surface is possibly explained by internalization.

Entities: Chemical Species

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Year: 1990 PMID： 2203828 PMCID： PMC296819 DOI： 10.1172/JCI114801

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

32 in total

1. Subdivision of hexagonal liver lobules into a structural and functional unit; role in hepatic physiology and pathology.

Authors: A M RAPPAPORT; Z J BOROWY; W M LOUGHEED; W N LOTTO
Journal: Anat Rec Date: 1954-05

2. Liver cell heterogeneity. The distribution of pyruvate kinase and phosphoenolpyruvate carboxykinase (GTP) in the liver lobule of fed and starved rats.

Authors: W G Guder; U Schmidt
Journal: Hoppe Seylers Z Physiol Chem Date: 1976-12

3. Functional heterogeneity of rat liver parenchyma and of isolated hepatocytes.

Authors: D Sasse; N Katz; K Jungermann
Journal: FEBS Lett Date: 1975-09-01 Impact factor: 4.124

4. Heterogeneous reciprocal localization of fructose-1,6-bisphosphatase and of glucokinase in microdissected periportal and perivenous rat liver tissue.

Authors: N Katz; H F Teutsch; K Jungermann; D Sasse
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5. RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination.

Authors: H Lehrach; D Diamond; J M Wozney; H Boedtker
Journal: Biochemistry Date: 1977-10-18 Impact factor: 3.162

6. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors: H Towbin; T Staehelin; J Gordon
Journal: Proc Natl Acad Sci U S A Date: 1979-09 Impact factor: 11.205

7. Stereospecific transport of glucose in the perfused rat liver.

Authors: T F Williams; J H Exton; C R Park; D M Regen
Journal: Am J Physiol Date: 1968-11

8. Hexokinase and glucokinase distribution in the liver lobule.

Authors: M Trus; K Zawalich; D Gaynor; F Matschinsky
Journal: J Histochem Cytochem Date: 1980-06 Impact factor: 2.479

9. Kinetics of 3-O-methyl-D-glucose transport in isolated rat hepatocytes.

Authors: J D Craik; K R Elliott
Journal: Biochem J Date: 1979-08-15 Impact factor: 3.857

10. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.

Authors: C Auffray; F Rougeon
Journal: Eur J Biochem Date: 1980-06

14 in total

Review 1. Enterohepatic circulation: physiological, pharmacokinetic and clinical implications.

Authors: Michael S Roberts; Beatrice M Magnusson; Frank J Burczynski; Michael Weiss
Journal: Clin Pharmacokinet Date: 2002 Impact factor: 6.447

2. Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation.

Authors: S P Burns; M Desai; R D Cohen; C N Hales; R A Iles; J P Germain; T C Going; R A Bailey
Journal: J Clin Invest Date: 1997-10-01 Impact factor: 14.808

3. Expression of facilitative glucose transporter in rat liver and choroid plexus. A histochemical study in native cryostat sections.

Authors: H J Hacker; B Thorens; R Grobholz
Journal: Histochemistry Date: 1991

Restricted expression of the erythroid/brain glucose transporter isoform to perivenous hepatocytes in rats. Modulation by glucose.

1. Subdivision of hexagonal liver lobules into a structural and functional unit; role in hepatic physiology and pathology.

2. Liver cell heterogeneity. The distribution of pyruvate kinase and phosphoenolpyruvate carboxykinase (GTP) in the liver lobule of fed and starved rats.

3. Functional heterogeneity of rat liver parenchyma and of isolated hepatocytes.

4. Heterogeneous reciprocal localization of fructose-1,6-bisphosphatase and of glucokinase in microdissected periportal and perivenous rat liver tissue.

5. RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination.

6. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

7. Stereospecific transport of glucose in the perfused rat liver.

8. Hexokinase and glucokinase distribution in the liver lobule.

9. Kinetics of 3-O-methyl-D-glucose transport in isolated rat hepatocytes.

10. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.

Review 1. Enterohepatic circulation: physiological, pharmacokinetic and clinical implications.

2. Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation.

3. Expression of facilitative glucose transporter in rat liver and choroid plexus. A histochemical study in native cryostat sections.

4. Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells.

5. Glucose transporter isotypes switch in T-antigen-transformed pancreatic beta cells growing in culture and in mice.

6. Chronic ethanol consumption disrupts diurnal rhythms of hepatic glycogen metabolism in mice.

7. Tissue and subcellular distribution of glucokinase in rat liver and their changes during fasting-refeeding.

8. High glucose potentiates L-FABP mediated fibrate induction of PPARα in mouse hepatocytes.

9. Functional expression of rat GLUT 1 glucose transporter in Dictyostelium discoideum.

10. Alterations in glucose transporter proteins in alcoholic liver disease in the rat.