OBJECTIVE: To date, no secondary prevention program is in place for patients carrying an increased risk for developing head and neck cancer (HNSCC). In terms of successful, long-term curative therapy and increased quality of life, it would be useful to detect such diseases at an early stage. PATIENTS AND METHODS: A total of 370 patients with at least one risk factor such as "smoking", "alcohol", or "reflux disease" and without any symptoms were examined during a 1-year period using standard HNO methods (e. g. endoscopy) for suspicious alterations of the mucosa of the upper aerodigestive tract. RESULTS: In 13 (3.5%) of all 370 cases a biopsy was taken for further diagnosis. Squamous cell carcinoma was found in eight cases, while one further patient was suffering from non-Hodgkin lymphoma. CONCLUSIONS: It is simple and safe to examine patients at risk of developing HNSCC by standard HNO methods. The rate of detected carcinomas is much higher than in former investigations, likely because our survey focused only on patients with specific risk factors.
OBJECTIVE: To date, no secondary prevention program is in place for patients carrying an increased risk for developing head and neck cancer (HNSCC). In terms of successful, long-term curative therapy and increased quality of life, it would be useful to detect such diseases at an early stage. PATIENTS AND METHODS: A total of 370 patients with at least one risk factor such as "smoking", "alcohol", or "reflux disease" and without any symptoms were examined during a 1-year period using standard HNO methods (e. g. endoscopy) for suspicious alterations of the mucosa of the upper aerodigestive tract. RESULTS: In 13 (3.5%) of all 370 cases a biopsy was taken for further diagnosis. Squamous cell carcinoma was found in eight cases, while one further patient was suffering from non-Hodgkin lymphoma. CONCLUSIONS: It is simple and safe to examine patients at risk of developing HNSCC by standard HNO methods. The rate of detected carcinomas is much higher than in former investigations, likely because our survey focused only on patients with specific risk factors.
Authors: A M Lessells; R A Burnett; J R Goodlad; S R Howatson; S Lang; F D Lee; K M McLaren; S Ogston; A J Robertson; J G Simpson; G D Smith; H B Tavadia; F Walker Journal: J Pathol Date: 2002-09 Impact factor: 7.996
Authors: Oliver Moschler; Thomas Werner Spahn; Christina Middelberg-Bisping; Wolfram Grosse-Thie; Bernd Christoph; Gunter Kloeppel; Michael Karl Mueller Journal: Digestion Date: 2006-07-11 Impact factor: 3.216
Authors: Luenda E Charles; Cecil M Burchfiel; Desta Fekedulegn; Ja K Gu; Helen Petrovitch; Wayne T Sanderson; Kamal Masaki; Beatriz L Rodriguez; Michael E Andrew; G Webster Ross Journal: Work Date: 2010
Authors: Andreas Dietz; Volker Rudat; Jens Dreyhaupt; Maria Pritsch; Florian Hoppe; Rudolph Hagen; Leo Pfreundner; Ursula Schröder; Hans Eckel; Markus Hess; Michael Schröder; Petra Schneider; Bünzel Jens; Hans P Zenner; Jochen A Werner; Rita Engenhardt-Cabillic; Bernhard Vanselow; Peter Plinkert; Marcus Niewald; Thomas Kuhnt; Wilfried Budach; Michael Flentje Journal: Eur Arch Otorhinolaryngol Date: 2008-10-30 Impact factor: 2.503