| Literature DB >> 22037801 |
Frank Lieberman1, Victor Yazbeck, Anastasios Raptis, Raymond Felgar, Michael Boyiadzis.
Abstract
Post-transplant lymphoproliferative disorder (PTLD) is a serious complication after allogeneic hematopoietic stem cell transplantation (HSCT). Extra nodal involvement is common in PTLD, but isolated involvement of the central nervous system (CNS) is extremely rare. Given the rarity of primary CNS-PTLD there is no consensus on optimal treatment. We report a patient who developed Epstein-Barr virus related primary CNS-PTLD following allogeneic HSCT who was treated with the monoclonal anti-CD20 antibody rituximab and reduction of immunosuppression. In addition, we review the literature and discuss treatment options for patients with primary CNS-PTLD following allogeneic HSCT.Entities:
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Year: 2011 PMID: 22037801 DOI: 10.1007/s11060-011-0739-6
Source DB: PubMed Journal: J Neurooncol ISSN: 0167-594X Impact factor: 4.130