| Literature DB >> 22037551 |
Yongyong Shi1, Zhibin Hu, Chen Wu, Juncheng Dai, Huizhang Li, Jing Dong, Meilin Wang, Xiaoping Miao, Yifeng Zhou, Feng Lu, Hanze Zhang, Lingmin Hu, Yue Jiang, Zhiqiang Li, Minjie Chu, Hongxia Ma, Jiaping Chen, Guangfu Jin, Wen Tan, Tangchun Wu, Zhengdong Zhang, Dongxin Lin, Hongbing Shen.
Abstract
Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9)). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.Entities:
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Year: 2011 PMID： 22037551 DOI： 10.1038/ng.978
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330