F O Omoregie1, M A Ojo, Bdo Saheeb, O Odukoya. 1. Department of Oral and Maxillofacial Surgery and Pathology, University of Benin, Benin City, Nigeria. omoregiefo@yahoo.com
Abstract
OBJECTIVE: This article aims to determine the incidence of periapical granuloma from extracted teeth and correlate the clinical diagnoses with the histopathological types of periapical granuloma. PATIENTS AND METHODS: Over a period of eight months, a prospective study designed as a routine biopsy of recoverable periapical tissues obtained from patients who had single tooth extraction was carried out. RESULTS: One hundred and thirty-six patients participated in the study, with 75 (55.1%) histopathologically diagnosed periradicular lesions. There were 23 (16.9%) cases of periapical granuloma, with a male to female ratio of 2: 1. The lesion presented mostly between the third and fourth decades of life (n=9, 6.6%). Clinically diagnosed acute apical periodontitis was significantly associated with periapical granuloma, with predominantly foamy macrophages and lymphocytes (P<0.05). CONCLUSION: Periapical granuloma appears to be a less common periapical lesion in this study compared to the previous reports. In contrast to reports that relate to an acute flare of the lesion with abundant neutrophilic infiltration, this study has shown marked foamy macrophages and lymphocytes at the acute phase, which are significantly associated with the clinical diagnosis of acute apical periodontitis. We recommend the classification of periapical granuloma into early, intermediate, and late stages of the lesion, based on the associated inflammatory cells.
OBJECTIVE: This article aims to determine the incidence of periapical granuloma from extracted teeth and correlate the clinical diagnoses with the histopathological types of periapical granuloma. PATIENTS AND METHODS: Over a period of eight months, a prospective study designed as a routine biopsy of recoverable periapical tissues obtained from patients who had single tooth extraction was carried out. RESULTS: One hundred and thirty-six patients participated in the study, with 75 (55.1%) histopathologically diagnosed periradicular lesions. There were 23 (16.9%) cases of periapical granuloma, with a male to female ratio of 2: 1. The lesion presented mostly between the third and fourth decades of life (n=9, 6.6%). Clinically diagnosed acute apical periodontitis was significantly associated with periapical granuloma, with predominantly foamy macrophages and lymphocytes (P<0.05). CONCLUSION: Periapical granuloma appears to be a less common periapical lesion in this study compared to the previous reports. In contrast to reports that relate to an acute flare of the lesion with abundant neutrophilic infiltration, this study has shown marked foamy macrophages and lymphocytes at the acute phase, which are significantly associated with the clinical diagnosis of acute apical periodontitis. We recommend the classification of periapical granuloma into early, intermediate, and late stages of the lesion, based on the associated inflammatory cells.
Authors: Isabela Dos Santos Alves; Daniela Ferreira Vieira Vendramini; Claudia da Costa Leite; Eloisa Maria Mello Santiago Gebrim; Ula Lindoso Passos Journal: Radiol Bras Date: 2021 Mar-Apr
Authors: Hong Li; Wenjing Luo; Anna Feng; Michelle L Tang; Terry B Kensler; Elizabeth Maldonado; Octavio A Gonzalez; Matthew J Kessler; Paul C Dechow; Jeffrey L Ebersole; Qian Wang Journal: Am J Phys Anthropol Date: 2018-08-20 Impact factor: 2.963