| Literature DB >> 22037050 |
Shuang-Xi Gu1, Shi-Qiong Yang, Qiu-Qin He, Xiao-Dong Ma, Fen-Er Chen, Hui-Fang Dai, Erik De Clercq, Jan Balzarini, Christophe Pannecouque.
Abstract
A series of 18 cycloalkyl arylpyrimidines (CAPYs) were designed from lead compounds diarylpyrimidines (DAPYs), synthesized and evaluated for in vitro anti-HIV activity. Among them, the compound 1p displayed potent anti-HIV-1 activity against WT HIV-1 with an EC(50) value of 0.055 μM and a selectivity index (SI) >7290. The preliminary structure-activity relationship (SAR) of this new series of compounds was also investigated, which enriched the SAR of diarylpyrimidines (DAPYs).Entities:
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Year: 2011 PMID： 22037050 DOI： 10.1016/j.bmc.2011.10.002
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641